Global Patent Index - EP 1060168 A2

EP 1060168 A2 2000-12-20 - METHOD FOR PREPARING SULFANYL-TYPE ENDOTHELIN RECEPTOR ANTAGONISTS

Title (en)

METHOD FOR PREPARING SULFANYL-TYPE ENDOTHELIN RECEPTOR ANTAGONISTS

Title (de)

VERFAHREN ZUR DARSTELLUNG VON ENDOTHELINREZEPTORANTAGONISTEN VOM SULFANYLTYP

Title (fr)

PROCEDE DE PREPARATION D'ANTAGONISTES DE RECEPTEURS D'ENDOTHELINE DE TYPE SULFANYLE

Publication

EP 1060168 A2 (DE)

Application

EP 99915535 A

Priority

  • DE 19809635 A
  • EP 9901209 W

Abstract (en)

[origin: DE19809635A1] The invention relates to a method for preparing sulfanyl-type endothelin receptor antagonists of general formula (I) wherein R<1> represents hydroxy, alkoxy, sulfonamidyl, amino; R<2> represents alkyl, aryl or heteroaryl, optionally substituted, and R<3>, R<4>, R<5> can be the same or different and are alkyl or aryl, optionally substituted, by means of nucleophilic reaction of a carboxylic acid derivative of formula (II) with a sulfide of formula (III), X being SR<6> or SO2R<6> and R<6> being alkyl or aryl, optionally substituted.

IPC 1-7 (main, further and additional classification)

C07D 239/60; C07C 323/22; C07D 317/56

IPC 8 full level (invention and additional information)

C07D 239/38 (2006.01); A61K 31/19 (2006.01); A61K 31/215 (2006.01); A61K 31/357 (2006.01); A61K 31/36 (2006.01); A61K 31/505 (2006.01); A61P 43/00 (2006.01); C07C 319/14 (2006.01); C07C 323/56 (2006.01); C07D 239/56 (2006.01); C07D 239/60 (2006.01); C07D 317/62 (2006.01)

CPC (invention and additional information)

C07C 319/14 (2013.01); C07D 239/60 (2013.01)

Citation (search report)

See references of WO 9944988A3

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

DE 19809635 A1 19990909; AR 018145 A1 20011031; AU 3408799 A 19990920; BG 104722 A 20010531; BR 9908585 A 20001121; CA 2322226 A1 19990910; CN 1292783 A 20010425; CO 4790169 A1 19990531; EP 1060168 A2 20001220; HR P20000649 A2 20010630; HU 0100857 A2 20010828; HU 0100857 A3 20011228; ID 26348 A 20001214; IL 137538 D0 20010724; JP 2002505319 A 20020219; NO 20004422 A 20000905; NO 20004422 D0 20000905; PL 343426 A1 20010813; SK 12012000 A3 20010118; TR 200002577 T2 20001121; US 6235903 B1 20010522; WO 9944988 A2 19990910; WO 9944988 A3 19991111; ZA 9901779 B 20001011

INPADOC legal status


2004-05-06 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20031028

2003-06-04 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030417

2003-05-07 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: ABBOTT GMBH & CO. KG

2000-12-20 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000727

2000-12-20 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-12-20 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: RO PAYMENT 20000727;SI PAYMENT 20000727