EP 1060194 A1 20001220 - ENHANCING THE CIRCULATING HALF-LIFE OF ANTIBODY-BASED FUSION PROTEINS
Title (en)
ENHANCING THE CIRCULATING HALF-LIFE OF ANTIBODY-BASED FUSION PROTEINS
Title (de)
VERLÄNGERUNG DER KREISLAUFHALBWERTZEIT VON ANTIKÖRPERFUSIONSPROTEINEN
Title (fr)
AMELIORATION DE LA DEMI-VIE CIRCULANTE DE PROTEINES HYBRIDES A BASE D'ANTICORPS
Publication
Application
Priority
- US 9903966 W 19990224
- US 7588798 P 19980225
Abstract (en)
[origin: WO9943713A1] Disclosed are methods for the genetic construction and expression of antibody-based fusion proteins with enhanced circulating half-lives. The fusion proteins of the present invention lack the ability to bind to immunoglobulin Fc receptors, either as a consequence of the antibody isotype used for fusion protein construction, or through directed mutagenesis of antibody isotypes that normally bind Fc receptors. The fusion proteins of the present invention may also contain a functional domain capable of binding an immunoglobulin protection receptor.
IPC 1-7
IPC 8 full level
C07K 14/52 (2006.01); C07K 14/53 (2006.01); C07K 14/55 (2006.01); C07K 14/705 (2006.01); C07K 14/73 (2006.01); C12N 15/09 (2006.01); C07K 19/00 (2006.01)
CPC (source: EP)
C07K 14/55 (2013.01); C07K 14/70514 (2013.01); C07K 2317/52 (2013.01); C07K 2319/00 (2013.01); C07K 2319/30 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9943713 A1 19990902; AU 2784299 A 19990915; AU 758240 B2 20030320; BR 9908226 A 20001024; CA 2320403 A1 19990902; CN 1204147 C 20050601; CN 1291995 A 20010418; CZ 20003099 A3 20020417; EP 1060194 A1 20001220; HK 1036286 A1 20011228; HU P0100813 A2 20010628; HU P0100813 A3 20030828; JP 2002505086 A 20020219; NO 20004218 D0 20000823; NO 20004218 L 20001024; PL 199659 B1 20081031; PL 342497 A1 20010604
DOCDB simple family (application)
US 9903966 W 19990224; AU 2784299 A 19990224; BR 9908226 A 19990224; CA 2320403 A 19990224; CN 99803277 A 19990224; CZ 20003099 A 19990224; EP 99908399 A 19990224; HK 01107082 A 20011009; HU P0100813 A 19990224; JP 2000533463 A 19990224; NO 20004218 A 20000823; PL 34249799 A 19990224