Global patent index - EP 1060194 A1

EP 1060194 A1 2000-12-20 - ENHANCING THE CIRCULATING HALF-LIFE OF ANTIBODY-BASED FUSION PROTEINS

Title (en)

ENHANCING THE CIRCULATING HALF-LIFE OF ANTIBODY-BASED FUSION PROTEINS

Title (de)

VERLÄNGERUNG DER KREISLAUFHALBWERTZEIT VON ANTIKÖRPERFUSIONSPROTEINEN

Title (fr)

AMELIORATION DE LA DEMI-VIE CIRCULANTE DE PROTEINES HYBRIDES A BASE D'ANTICORPS

Publication

EP 1060194 A1 (EN)

Application

EP 99908399 A

Priority

  • US 9903966 W
  • US 7588798 P

Abstract (en)

[origin: WO9943713A1] Disclosed are methods for the genetic construction and expression of antibody-based fusion proteins with enhanced circulating half-lives. The fusion proteins of the present invention lack the ability to bind to immunoglobulin Fc receptors, either as a consequence of the antibody isotype used for fusion protein construction, or through directed mutagenesis of antibody isotypes that normally bind Fc receptors. The fusion proteins of the present invention may also contain a functional domain capable of binding an immunoglobulin protection receptor.

IPC 1-7 (main, further and additional classification)

C07K 19/00

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); C07K 14/52 (2006.01); C07K 14/53 (2006.01); C07K 14/55 (2006.01); C07K 14/705 (2006.01); C07K 14/73 (2006.01); C07K 19/00 (2006.01)

CPC (invention and additional information)

C07K 14/55 (2013.01); C07K 14/70514 (2013.01); C07K 2317/52 (2013.01); C07K 2319/00 (2013.01); C07K 2319/30 (2013.01)

Citation (search report)

See references of WO 9943713A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9943713 A1 19990902; AU 2784299 A 19990915; AU 758240 B2 20030320; BR 9908226 A 20001024; CA 2320403 A1 19990902; CN 1204147 C 20050601; CN 1291995 A 20010418; CZ 20003099 A3 20020417; EP 1060194 A1 20001220; HK 1036286 A1 20060120; HU 0100813 A2 20010628; HU 0100813 A3 20030828; JP 2002505086 A 20020219; NO 20004218 A 20001024; NO 20004218 D0 20000823; PL 199659 B1 20081031; PL 342497 A1 20010604

INPADOC legal status

2010-02-03 [18R] REFUSED

- Ref Legal Event Code: 18R

- Effective date: 20090925

2008-06-25 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: MERCK PATENT GMBH

- Ref Legal Event Code: RAP1

2003-09-17 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20030804

2000-12-20 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20001011

2000-12-20 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-12-20 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Ref Legal Event Code: AX

- Free Format Text: LT PAYMENT 20001011;LV PAYMENT 20001011;RO PAYMENT 20001011;SI PAYMENT 20001011