EP 1060244 A1 20001220 - PLURIPOTENT EMBRYONIC STEM CELLS AND METHODS OF OBTAINING THEM
Title (en)
PLURIPOTENT EMBRYONIC STEM CELLS AND METHODS OF OBTAINING THEM
Title (de)
PLURIPOTENT EMBRYONALE STAMMZELLEN UND VERFAHREN ZU DEREN HERSTELLUNG
Title (fr)
CELLULES SOUCHES EMBRYONNAIRES MULTIPOTENTES ET PROCEDES PERMETTANT DE LES OBTENIR
Publication
Application
Priority
- US 9825283 W 19981125
- US 6689097 P 19971125
- US 19970398 A 19981124
Abstract (en)
[origin: CA2311396A1] The present invention provides an isolated population of non-mouse embryonic stem (ES) cells and methods of obtaining these ES cells. In one aspect, the target ES cells are obtained by co-culturing embryo cells from a target animal with non-target ES cells, such as mouse ES cells. In one embodiment, rat ES cells are isolated from the co-culture using positive or negative selectable markers. The invention also includes genetically modified non-mouse ES cells. Chimeric embryos and animals containing isolated populations of the ES cells or genetically modified ES cells are also provided. In one embodiment, the genetic modification comprises introduction of a transgene. In another embodiment, the genetic modification comprises disruption of the function of one or more genes.
IPC 1-7
IPC 8 full level
A01K 67/027 (2006.01); C12N 5/06 (2006.01); C12N 5/0735 (2010.01); C12N 5/08 (2006.01)
CPC (source: EP US)
A01K 67/0271 (2013.01 - EP); C12N 5/0606 (2013.01 - EP US); C12N 2510/00 (2013.01 - EP)
Citation (search report)
See references of WO 9927076A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
AU 1704899 A 19990615; AU 762112 B2 20030619; CA 2311396 A1 19990603; CN 1284993 A 20010221; EP 1060244 A1 20001220; IL 136347 A0 20010520; JP 2002527036 A 20020827; NZ 504784 A 20031219
DOCDB simple family (application)
AU 1704899 A 19981125; CA 2311396 A 19981125; CN 98812935 A 19981125; EP 98961813 A 19981125; IL 13634798 A 19981125; JP 2000522218 A 19981125; NZ 50478498 A 19981125