Global Patent Index - EP 1060268 A2

EP 1060268 A2 2000-12-20 - METHODS FOR IDENTIFYING POLYCATIONIC, PEPTIDE-LIKE COMPOUNDS WITH ANTIBACTERIAL ACTIVITY

Title (en)

METHODS FOR IDENTIFYING POLYCATIONIC, PEPTIDE-LIKE COMPOUNDS WITH ANTIBACTERIAL ACTIVITY

Title (de)

VERFAHREN ZUR IDENTIFIZIERUNG VON POLYKATIONISCHEN, PEPTIDARTIGEN VERBINDUNGEN MIT ANTIBAKTERIELLEN WIRKUNG

Title (fr)

METHODES D'IDENTIFICATION DE COMPOSES POLYCATIONIQUES, DE TYPE PEPTIDIQUE, A ACTION ANTIBACTERIENNE

Publication

EP 1060268 A2 (EN)

Application

EP 99909832 A

Priority

  • US 9904795 W
  • US 7702598 P
  • US 10025798 P

Abstract (en)

[origin: WO9945152A1] A method is provided for identifying polycationic, peptide-like compounds characterized by antibacterial activity against gram negative bacteria. The method takes advantage of the induction of hyperosomotic stress without leakage of cytoplasmic content. The method involves determining whether the compound has the ability to produce phospholipid exchange betwen the lipid bilayers in conjunction with the induction of the osmotic stress response in the target cell. Determining the induction of the osmotic stress response is effected using a bioluminescent detector organism having a osmY-LUX gene fusion.

IPC 1-7 (main, further and additional classification)

C12Q 1/68; C12Q 1/02; C12Q 1/66

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); C12N 15/53 (2006.01); C12Q 1/02 (2006.01); C12Q 1/66 (2006.01); C12Q 1/68 (2006.01)

CPC (invention and additional information)

C12Q 1/6897 (2013.01)

Citation (search report)

See references of WO 9945152A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9945152 A1 19990910; WO 9945152 A8 19991007; AU 2895099 A 19990920; CA 2321931 A1 19990910; EP 1060268 A2 20001220; IL 137934 D0 20011031; JP 2002505120 A 20020219

INPADOC legal status


2005-04-06 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20041001

2000-12-20 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000906

2000-12-20 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE