EP 1061866 A4 20030716 - BONE XENOGRAFTS
Title (en)
BONE XENOGRAFTS
Title (de)
KNOCHENXENOTRANSPLANTATE
Title (fr)
XENOGREFFES OSSEUSES
Publication
Application
Priority
- US 9905661 W 19990315
- US 7813998 P 19980316
- US 10075598 P 19980917
Abstract (en)
[origin: WO9947080A1] The invention provides an article of manufacture comprising a substantially non-immunogenic bone xenograft for implantation into humans. The invention further provides a method for preparing a bone xenograft by removing at least a portion of a bone from a non-human animal to provide a xenograft (X); washing the xenograft in saline and alcohol; subjecting the xenograft to a cellular disruption treatment; and treating the xenograft with a glycosidase to remove surface carbohydrate moieties. The invention also provides an article of manufacture produced by the above identified method of invention. The invention further provides a bone xenograft for implantation into a human including a portion (10) of a bone from a nonhuman animal, wherein the portion has substantially no surface carbohydrate moieties which are susceptible to glycosidase digestion. Each xenograft of the invention has substantially the same mechanical properties as a corresponding native bone.
IPC 1-7
IPC 8 full level
A61F 2/28 (2006.01); A61L 27/36 (2006.01); A61F 2/30 (2006.01)
CPC (source: EP)
A61F 2/28 (2013.01); A61L 2/204 (2013.01); A61L 2/206 (2013.01); A61L 27/36 (2013.01); A61L 27/3608 (2013.01); A61L 27/365 (2013.01); A61L 27/3687 (2013.01); A61L 27/3691 (2013.01); A61F 2/3094 (2013.01); A61F 2002/2835 (2013.01); A61L 2430/02 (2013.01)
Citation (search report)
- [XY] US 5333626 A 19940802 - MORSE BRENDA S [US], et al
- [XY] GB 2175507 A 19861203 - AMERICAN HOSPITAL SUPPLY CORP
- [XY] US 5314476 A 19940524 - PREWETT ANNAMARIE B [US], et al
- [XY] WO 9612509 A1 19960502 - OLIVA GIUSEPPE [IT], et al
- [E] WO 9944533 A1 19990910 - CROSSCART INC [US], et al
- [Y] GALILI U ET AL: "HIGH-AFFINITY ANTI-GAL IMMUNOGLOBULIN G IN CHRONIC REJECTION OF XENOGRAFTS", XENOTRANSPLANTATION, MUNKSGAARD, DE, vol. 4, no. 3, August 1997 (1997-08-01), pages 127 - 131, XP009009159, ISSN: 0908-665X
- [Y] GALILI U ET AL: "PORCINE AND BOVINE CARTILAGE TRANSPLANTS IN CYNOMOLGUS MONKEY II. CHANGES IN ANTI-GAL RESPONSE DURING CHRONIC REJECTION", TRANSPLANTATION, WILLIAMS AND WILKINS, BALTIMORE, MD, US, vol. 63, no. 5, 15 March 1997 (1997-03-15), pages 646 - 651, XP009009157, ISSN: 0041-1337
- See references of WO 9947080A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9947080 A1 19990923; AU 3186899 A 19991011; AU 755316 B2 20021212; CA 2323866 A1 19990923; EP 1061866 A1 20001227; EP 1061866 A4 20030716; JP 2002506677 A 20020305
DOCDB simple family (application)
US 9905661 W 19990315; AU 3186899 A 19990315; CA 2323866 A 19990315; EP 99913897 A 19990315; JP 2000536323 A 19990315