Global patent index - EP 1062218 A1

EP 1062218 A1 2000-12-27 - MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases)

Title (en)

MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases)

Title (de)

MODULATOREN DER PROTEIN-TYROSIN-PHOSPHATASEN (PTPHASEN)

Title (fr)

MODULATEURS DE PROTEINE TYROSINE PHOSPHATASES (PTPases)

Publication

EP 1062218 A1 (EN)

Application

EP 99908770 A

Priority

  • DK 9900124 W
  • DK 34698 A
  • DK 34798 A
  • DK 34898 A
  • DK 47498 A
  • DK 47598 A
  • DK 47698 A

Abstract (en)

[origin: WO9946268A1] The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases) such as PTP1B, CD45, SHP-1, SHP-2, PTP alpha , LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

IPC 1-7 (main, further and additional classification)

C07D 513/04; A61K 31/385; A61K 31/495; C07D 497/04

IPC 8 full level (invention and additional information)

C07D 237/28 (2006.01); A61K 31/385 (2006.01); A61K 31/429 (2006.01); A61K 31/4355 (2006.01); A61K 31/4365 (2006.01); A61K 31/437 (2006.01); A61K 31/4375 (2006.01); A61K 31/47 (2006.01); A61K 31/472 (2006.01); A61K 31/495 (2006.01); A61K 31/4985 (2006.01); A61K 31/502 (2006.01); A61K 31/5025 (2006.01); A61K 31/517 (2006.01); A61K 31/519 (2006.01); A61P 3/06 (2006.01); A61P 3/10 (2006.01); A61P 5/10 (2006.01); A61P 7/02 (2006.01); A61P 11/06 (2006.01); A61P 17/06 (2006.01); A61P 19/10 (2006.01); A61P 25/00 (2006.01); A61P 25/18 (2006.01); A61P 25/28 (2006.01); A61P 31/04 (2006.01); A61P 35/00 (2006.01); A61P 37/06 (2006.01); A61P 37/08 (2006.01); C07C 233/56 (2006.01); C07C 237/22 (2006.01); C07D 207/34 (2006.01); C07D 209/08 (2006.01); C07D 209/14 (2006.01); C07D 213/79 (2006.01); C07D 213/80 (2006.01); C07D 215/38 (2006.01); C07D 217/22 (2006.01); C07D 231/40 (2006.01); C07D 237/30 (2006.01); C07D 239/42 (2006.01); C07D 239/557 (2006.01); C07D 239/86 (2006.01); C07D 241/44 (2006.01); C07D 261/08 (2006.01); C07D 271/10 (2006.01); C07D 333/38 (2006.01); C07D 333/66 (2006.01); C07D 333/68 (2006.01); C07D 409/04 (2006.01); C07D 409/06 (2006.01); C07D 413/04 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 491/048 (2006.01); C07D 495/04 (2006.01); C07D 495/10 (2006.01); C07D 495/14 (2006.01); C07D 513/04 (2006.01); C07D 239/54 (2006.01)

CPC (invention and additional information)

C07D 213/79 (2013.01); C07C 233/56 (2013.01); C07C 237/22 (2013.01); C07D 207/34 (2013.01); C07D 209/08 (2013.01); C07D 209/14 (2013.01); C07D 213/80 (2013.01); C07D 231/40 (2013.01); C07D 239/42 (2013.01); C07D 239/557 (2013.01); C07D 261/08 (2013.01); C07D 271/10 (2013.01); C07D 333/38 (2013.01); C07D 333/66 (2013.01); C07D 333/68 (2013.01); C07D 409/04 (2013.01); C07D 409/06 (2013.01); C07D 413/04 (2013.01); C07D 495/04 (2013.01); C07D 495/10 (2013.01); C07D 495/14 (2013.01)

Citation (search report)

See references of WO 9946268A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9946268 A1 19990916; AU 2825899 A 19990927; EP 1062218 A1 20001227; JP 2002506073 A 20020226

INPADOC legal status

2002-10-02 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20020327

2002-01-02 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20011116

2000-12-27 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20001012

2000-12-27 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE