Global Patent Index - EP 1062320 A1

EP 1062320 A1 2000-12-27 - METHODS AND COMPOSITIONS FOR THE SELECTIVE EXPANSION OF GAMMA/DELTA T-CELLS

Title (en)

METHODS AND COMPOSITIONS FOR THE SELECTIVE EXPANSION OF GAMMA/DELTA T-CELLS

Title (de)

METHODEN UND ZUSAMMENSETZUNGEN FÜR DIE SELEKTIVE AUSBREITUNG VON GAMMA/DELTA T-ZELLEN

Title (fr)

METHODES ET COMPOSITIONS DE DEVELOPPEMENT SELECTIF DE LYMPHOCYTES T GAMMA/DELTA

Publication

EP 1062320 A1 (EN)

Application

EP 99911325 A

Priority

  • US 9905355 W
  • US 7772998 P

Abstract (en)

[origin: WO9946365A1] The present invention provides a method of increasing the percentage of gamma/delta T-cells in a population of hematolymphoid cells and which gamma/delta T-cells can survive for a prolonged period, comprising: a) contacting a population of hematolymphoid cells with interleukin 12 and a ligand of CD2 which induces responsiveness to interleukin 12; and b) contacting the cells of step (a) with an antibody to CD3 and interleukin-2. The present invention also provides a method of treating cancer, treating an infection, promoting wound healing and enhancing bone marrow engraftment in a subject comprising administering to the subject an effective amount of the cells of this invention.

IPC 1-7 (main, further and additional classification)

C12N 5/00; A61K 38/19; A61K 38/20; A61K 38/21; A61K 49/00; C12N 5/06; C12N 5/08; G01N 33/53; G01N 33/567

IPC 8 full level (invention and additional information)

A61K 38/20 (2006.01); A61K 39/395 (2006.01); C07K 16/28 (2006.01); C12N 5/0783 (2010.01); A61K 35/12 (2006.01)

CPC (invention and additional information)

C12N 5/0636 (2013.01); A61K 38/208 (2013.01); A61K 39/395 (2013.01); C07K 16/2806 (2013.01); C07K 16/2809 (2013.01); A61K 2035/124 (2013.01); A61K 2039/505 (2013.01); C12N 2501/23 (2013.01); C12N 2501/24 (2013.01); C12N 2501/599 (2013.01); G01N 2333/54 (2013.01)

Combination set (CPC)

  1. A61K 38/208 + A61K 2300/00
  2. A61K 39/395 + A61K 2300/00

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9946365 A1 19990916; AU 2999299 A 19990927; AU 746531 B2 20020502; CA 2323080 A1 19990916; EP 1062320 A1 20001227; EP 1062320 A4 20030102

INPADOC legal status


2003-06-04 [18W] WITHDRAWN

- Ref Legal Event Code: 18W

- Effective date: 20030318

2003-01-02 [A4] SUPPLEMENTARY SEARCH REPORT

- Ref Legal Event Code: A4

- Effective date: 20021115

2003-01-02 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-03-14 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: EMORY UNIVERSITY

- Ref Legal Event Code: RAP1

2001-03-14 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: STANFORD UNIVERSITY

- Ref Legal Event Code: RAP1

2000-12-27 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20001012

2000-12-27 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE