Global Patent Index - EP 1062320 A1

EP 1062320 A1 20001227 - METHODS AND COMPOSITIONS FOR THE SELECTIVE EXPANSION OF GAMMA/DELTA T-CELLS

Title (en)

METHODS AND COMPOSITIONS FOR THE SELECTIVE EXPANSION OF GAMMA/DELTA T-CELLS

Title (de)

METHODEN UND ZUSAMMENSETZUNGEN FÜR DIE SELEKTIVE AUSBREITUNG VON GAMMA/DELTA T-ZELLEN

Title (fr)

METHODES ET COMPOSITIONS DE DEVELOPPEMENT SELECTIF DE LYMPHOCYTES T GAMMA/DELTA

Publication

EP 1062320 A1 20001227 (EN)

Application

EP 99911325 A 19990312

Priority

  • US 9905355 W 19990312
  • US 7772998 P 19980312

Abstract (en)

[origin: WO9946365A1] The present invention provides a method of increasing the percentage of gamma/delta T-cells in a population of hematolymphoid cells and which gamma/delta T-cells can survive for a prolonged period, comprising: a) contacting a population of hematolymphoid cells with interleukin 12 and a ligand of CD2 which induces responsiveness to interleukin 12; and b) contacting the cells of step (a) with an antibody to CD3 and interleukin-2. The present invention also provides a method of treating cancer, treating an infection, promoting wound healing and enhancing bone marrow engraftment in a subject comprising administering to the subject an effective amount of the cells of this invention.

IPC 1-7

C12N 5/00; C12N 5/06; C12N 5/08; A61K 38/19; A61K 38/20; A61K 38/21; A61K 49/00; G01N 33/53; G01N 33/567

IPC 8 full level

A61K 38/20 (2006.01); A61K 39/395 (2006.01); C07K 16/28 (2006.01); C12N 5/0783 (2010.01); A61K 35/12 (2015.01); A61K 39/00 (2006.01)

CPC (source: EP)

A61K 38/208 (2013.01); A61K 39/395 (2013.01); A61K 39/4611 (2023.05); A61K 39/4621 (2023.05); A61K 39/46434 (2023.05); A61K 39/4644 (2023.05); C07K 16/2806 (2013.01); C07K 16/2809 (2013.01); C12N 5/0636 (2013.01); A61K 2035/124 (2013.01); A61K 2039/505 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); C12N 2501/23 (2013.01); C12N 2501/24 (2013.01); C12N 2501/599 (2013.01); G01N 2333/54 (2013.01)

C-Set (source: EP)

  1. A61K 38/208 + A61K 2300/00
  2. A61K 39/395 + A61K 2300/00

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9946365 A1 19990916; AU 2999299 A 19990927; AU 746531 B2 20020502; CA 2323080 A1 19990916; EP 1062320 A1 20001227; EP 1062320 A4 20030102

DOCDB simple family (application)

US 9905355 W 19990312; AU 2999299 A 19990312; CA 2323080 A 19990312; EP 99911325 A 19990312