Global Patent Index - EP 1062322 A2

EP 1062322 A2 2000-12-27 - A LIVING CHIMERIC SKIN REPLACEMENT

Title (en)

A LIVING CHIMERIC SKIN REPLACEMENT

Title (de)

LEBENDER CHIMÄRER HAUTERSATZ

Title (fr)

MATIERE DE RECONSTITUTION DE PEAU CHIMERE ET VIVANTE

Publication

EP 1062322 A2 (EN)

Application

EP 99936092 A

Priority

  • US 9903859 W
  • US 7570498 P

Abstract (en)

[origin: WO9943787A2] The invention comprises skin replacements for improved wound healing. In one embodiment, the skin replacement is chimeric and comprises harvesting autologous epithelial cells from a patient and seeding them onto a biocompatible substrate containing allogeneic epithelial cells cultured in vitro. The living chimeric skin replacement may be implanted over a permanent dermal replacement previously implanted at the wound site. In another embodiment the skin replacement is a composite comprising an inner, middle and outer component, comprising (a) an inner component comprising a biocompatible dermal construct having a biodegradable or removable scaffold as a base; (b) a middle component comprising epithelial cells; and (c) an outer component comprising epithelial cells cultured in vitro on a dermal construct comprising a dermal portion having a biodegradable or removable scaffold as a base, said dermal portion being combined with a transitional covering and facing inward toward said middle component of epithelial cells. The invention further comprises methods of making and implanting the various skin replacements of the invention.

IPC 1-7 (main, further and additional classification)

C12N 5/06; A61K 35/36; A61L 27/00; C12N 5/08; C12N 5/10

IPC 8 full level (invention and additional information)

A61K 35/36 (2006.01); A61L 27/00 (2006.01); A61L 27/60 (2006.01); A61P 17/02 (2006.01); A61P 43/00 (2006.01); C12N 5/071 (2010.01); C12N 5/10 (2006.01); A61K 35/12 (2006.01)

CPC (invention and additional information)

C12N 5/0698 (2013.01); A61L 27/60 (2013.01); A61K 35/12 (2013.01); C12N 2502/094 (2013.01); C12N 2502/1323 (2013.01)

Citation (search report)

See references of WO 9943787A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9943787 A2 19990902; WO 9943787 A3 19991125; AU 3307799 A 19990915; AU 760470 B2 20030515; CA 2324452 A1 19990902; EP 1062322 A2 20001227; JP 2002504412 A 20020212; NZ 506510 A 20030328

INPADOC legal status


2005-01-12 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20040707

2004-06-09 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: T.J. SMITH & NEPHEW LIMITED

2004-04-14 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20040225

2000-12-27 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000901

2000-12-27 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE