EP 1062322 A2 20001227 - A LIVING CHIMERIC SKIN REPLACEMENT
Title (en)
A LIVING CHIMERIC SKIN REPLACEMENT
Title (de)
LEBENDER CHIMÄRER HAUTERSATZ
Title (fr)
MATIERE DE RECONSTITUTION DE PEAU CHIMERE ET VIVANTE
Publication
Application
Priority
- US 9903859 W 19990223
- US 7570498 P 19980224
Abstract (en)
[origin: WO9943787A2] The invention comprises skin replacements for improved wound healing. In one embodiment, the skin replacement is chimeric and comprises harvesting autologous epithelial cells from a patient and seeding them onto a biocompatible substrate containing allogeneic epithelial cells cultured in vitro. The living chimeric skin replacement may be implanted over a permanent dermal replacement previously implanted at the wound site. In another embodiment the skin replacement is a composite comprising an inner, middle and outer component, comprising (a) an inner component comprising a biocompatible dermal construct having a biodegradable or removable scaffold as a base; (b) a middle component comprising epithelial cells; and (c) an outer component comprising epithelial cells cultured in vitro on a dermal construct comprising a dermal portion having a biodegradable or removable scaffold as a base, said dermal portion being combined with a transitional covering and facing inward toward said middle component of epithelial cells. The invention further comprises methods of making and implanting the various skin replacements of the invention.
IPC 1-7
IPC 8 full level
A61K 35/36 (2006.01); A61L 27/00 (2006.01); A61L 27/60 (2006.01); A61P 17/02 (2006.01); A61P 43/00 (2006.01); C12N 5/06 (2006.01); C12N 5/071 (2010.01); C12N 5/10 (2006.01); A61K 35/12 (2006.01)
CPC (source: EP KR)
A61L 27/60 (2013.01 - EP); A61P 17/02 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C12N 5/0602 (2013.01 - KR); C12N 5/0698 (2013.01 - EP); A61K 35/12 (2013.01 - EP); C12N 2502/094 (2013.01 - EP); C12N 2502/1323 (2013.01 - EP)
Citation (search report)
See references of WO 9943787A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9943787 A2 19990902; WO 9943787 A3 19991125; AU 3307799 A 19990915; AU 760470 B2 20030515; CA 2324452 A1 19990902; EP 1062322 A2 20001227; JP 2002504412 A 20020212; KR 20010072553 A 20010731; NZ 506510 A 20030328
DOCDB simple family (application)
US 9903859 W 19990223; AU 3307799 A 19990223; CA 2324452 A 19990223; EP 99936092 A 19990223; JP 2000533527 A 19990223; KR 20007009299 A 20000823; NZ 50651099 A 19990223