Global Patent Index - EP 1062328 A1

EP 1062328 A1 2000-12-27 - SUICIDE GENE THERAPY SYSTEM FOR THE TREATMENT OF BRAIN TUMOURS

Title (en)

SUICIDE GENE THERAPY SYSTEM FOR THE TREATMENT OF BRAIN TUMOURS

Title (de)

SELBSTMORDGEN-THERAPIESYSTEM ZUR BEHANDLUNG VON GEHIRNTUMOREN

Title (fr)

SYSTEME THERAPEUTIQUE A GENE SUICIDE POUR LE TRAITEMENT DES TUMEURS CEREBRALES

Publication

EP 1062328 A1 (EN)

Application

EP 99914502 A

Priority

  • EP 99914502 A
  • EP 9901541 W
  • EP 98104756 A

Abstract (en)

[origin: EP0943680A1] In a suicide gene therapy system, a DNA molecule encoding a glycosidase is applied with a non-toxic cyanogenic glycoside substrate, which upon degradation by the glycosidase yields hydrogen cyanide, for the treatment of brain tumours in animals or humans. The DNA preferably encodes linamarase, the substrate is preferably linamarin. The two interacting components are administered separately. <IMAGE>

IPC 1-7 (main, further and additional classification)

C12N 9/42; A61K 48/00

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 9/127 (2006.01); A61K 31/70 (2006.01); A61K 31/7088 (2006.01); A61K 35/76 (2006.01); A61K 38/47 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C12N 7/00 (2006.01); C12N 9/24 (2006.01); C12N 9/42 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

A61K 38/47 (2013.01); C12N 9/2445 (2013.01); C12Y 302/01021 (2013.01); A61K 48/00 (2013.01); C12N 2799/021 (2013.01)

Citation (search report)

See references of WO 9947653A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

EP 0943680 A1 19990922; AR 014733 A1 20010328; AU 3329999 A 19991011; CA 2323897 A1 19990923; CO 5080825 A1 20010925; EP 1062328 A1 20001227; JP 2002506885 A 20020305; WO 9947653 A1 19990923; ZA 9902063 B 19990917

INPADOC legal status


2004-07-28 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20040113

2004-01-14 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

2003-08-13 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030630

2000-12-27 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20001017

2000-12-27 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE