Global Patent Index - EP 1063887 A1

EP 1063887 A1 2001-01-03 - P53-DEPENDENT SECRETION OF GROWTH INHIBITORY FACTORS

Title (en)

P53-DEPENDENT SECRETION OF GROWTH INHIBITORY FACTORS

Title (de)

P53-ABHÄMGIGE SEKRETION VON WACHSTUMSINHIBIERENDEN FAKTOREN.

Title (fr)

SECRETION DE FACTEURS INHIBITEURS DE CROISSANCE DEPENDANT DE P53

Publication

EP 1063887 A1 (EN)

Application

EP 99908335 A

Priority

  • US 9903777 W
  • US 7549098 P
  • US 8475598 P

Abstract (en)

[origin: WO9941985A1] The present invention relates to a method for preparing a preparation of p53-dependent growth inhibitory factors for use in a pharmaceutical composition. Cultured human cells, capable of expressing p53 tumor suppressor protein, are induced to express and secrete p53-dependent growth inhibitory factors into the culture medium, where the growth inhibitory factors are recovered to prepare a preparation for use in a pharmaceutical composition. This pharmaceutical composition is then used in a method for reducing unwanted or abnormal cell proliferation by administering an effective amount to a subject in need thereof.

IPC 1-7 (main, further and additional classification)

A01N 37/18

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 38/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 14/495 (2006.01); C07K 14/575 (2006.01); C07K 14/81 (2006.01); C12N 5/10 (2006.01)

CPC (invention and additional information)

C07K 14/495 (2013.01); C07K 14/575 (2013.01); C07K 14/811 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9941985A1

Designated contracting state (EPC)

AT BE CH DE FR GB IT LI LU

EPO simple patent family

WO 9941985 A1 19990826; AU 2779499 A 19990906; CA 2321132 A1 19990826; EP 1063887 A1 20010103; IL 137939 D0 20011031; JP 2002503488 A 20020205

INPADOC legal status


2003-03-26 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20020829

2001-03-07 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: QUARK BIOTECH, INC.

2001-03-07 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINO

2001-01-03 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000824

2001-01-03 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE FR GB IT LI LU