EP 1063887 A1 20010103 - P53-DEPENDENT SECRETION OF GROWTH INHIBITORY FACTORS
Title (en)
P53-DEPENDENT SECRETION OF GROWTH INHIBITORY FACTORS
Title (de)
P53-ABHÄMGIGE SEKRETION VON WACHSTUMSINHIBIERENDEN FAKTOREN.
Title (fr)
SECRETION DE FACTEURS INHIBITEURS DE CROISSANCE DEPENDANT DE P53
Publication
Application
Priority
- US 9903777 W 19990223
- US 7549098 P 19980223
- US 8475598 P 19980508
Abstract (en)
[origin: WO9941985A1] The present invention relates to a method for preparing a preparation of p53-dependent growth inhibitory factors for use in a pharmaceutical composition. Cultured human cells, capable of expressing p53 tumor suppressor protein, are induced to express and secrete p53-dependent growth inhibitory factors into the culture medium, where the growth inhibitory factors are recovered to prepare a preparation for use in a pharmaceutical composition. This pharmaceutical composition is then used in a method for reducing unwanted or abnormal cell proliferation by administering an effective amount to a subject in need thereof.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 14/495 (2006.01); C07K 14/575 (2006.01); C07K 14/81 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07K 14/495 (2013.01); C07K 14/575 (2013.01); C07K 14/811 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9941985A1
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU
DOCDB simple family (publication)
WO 9941985 A1 19990826; AU 2779499 A 19990906; CA 2321132 A1 19990826; EP 1063887 A1 20010103; IL 137939 A0 20011031; JP 2002503488 A 20020205
DOCDB simple family (application)
US 9903777 W 19990223; AU 2779499 A 19990223; CA 2321132 A 19990223; EP 99908335 A 19990223; IL 13793999 A 19990223; JP 2000532012 A 19990223