EP 1064287 A1 20010103 - USE OF AMINOPHOSPHONATES AS 31 P-NMR PH INDICATORS
Title (en)
USE OF AMINOPHOSPHONATES AS 31 P-NMR PH INDICATORS
Title (de)
VERWENDUNG VON AMINOPHOSPHONATEN ALS PH-MARKERS IN 31 P-MNR
Title (fr)
UTILISATION D'AMINOPHOSPHONATES COMME MARQUEURS DE PH EN RMN DU 31 P
Publication
Application
Priority
- FR 9900631 W 19990318
- FR 9803317 A 19980318
Abstract (en)
[origin: FR2776293A1] Phosphonate derivatives ((I) and (II)), are new.- DETAILED DESCRIPTION - Phosphonate derivatives of formulae (I) and (II) are new.- R = 1-18C alkyl or 6 - 10C aryl; - R1,R2 = deuterium, halogen, 1-18C alkyl (optionally substituted by one or more 1-6C alkoxy, 3-11C cycloalkyl, halogen, 6-10C aryl, and nitro), 6-10C aryl (optionally substituted by one or more 1-6C alkyl or alkoxy, 3-11C cycloalkyl, halogen, and nitro), 1-18C alkoxy (optionally substituted by one or more 1-6C alkoxy, 3-11C cycloalkyl, halogen, 6-10C aryl, and nitro), nitro, 3-11C cycloalkyl (optionally substituted by one or more 1-6C alkyl or alkoxy, halogen, and nitro); - R3 = H, deuterium, n-propyl, 5-18C linear alkyl (optionally substituted by one or more 1-6C alkoxy, 3-11C cycloalkyl, halogen), or 3-11C cycloalkyl (optionally substituted by one or more 1-6C alkyl or alkoxy, halogen, and nitro); - R' = H or R; - R'1 = H or R1; - R'2 +R'3 = a bivalent radical of formula (a); - L1, L2, L3, and L4 = H, deuterium, 1-18C alkyl, or 6-10C aryl; provided that - when R'1 = H, deuterium, halogen, 1-18C alkoxy (optionally substituted), nitro, or 3-11C cycloalkyl; - L5 and L6 = H, deuterium, 1-18C alkyl, 6-10C aryl or P(O)(OR')2; - when R'1 = optionally substituted 1-18C alkyl, or 6-10C aryl; - one of L5 and L6 = H and the other is 2-18C alkyl or 6-10C aryl; and - when R'1 = methyl; L1- L5 is H, R' is ethyl, then L6 is not isopropyl.- INDEPENDENT CLAIMS are also included for the use of compounds of formula (IV) and (V) and their salts as 31P NMR pH indicators.- T1 and T2 = R or OR; - R1a and R2a = P(O)(OR)2, deuterium, halogen, 1-18C alkyl (optionally substituted by one or more 1-6C alkoxy, 3-11C cycloalkyl, halogen, 6-10C aryl, and nitro), 6-10C aryl (optionally substituted by one or more 1-6C alkyl or alkoxy, 3-11C cycloalkyl, halogen, and nitro), 1-18C alkoxy (optionally substituted by one or more 1-6C alkoxy, 3-11C cycloalkyl, halogen, 6-10C aryl, and nitro), nitro, 3-11C cycloalkyl (optionally substituted by one or more 1-6C alkyl or alkoxy, halogen, and nitro); - R3a = H or deuterium, 1-18C alkyl, (optionally substituted by one or more 1-6C alkoxy, 3-11C cycloalkyl, halogen, 6-10C aryl, and nitro, or by P(O)(OR)2 in the 1 position), 3-11C cycloalkyl, (optionally substituted by one or more 1-6C alkyl or alkoxy, halogen, and nitro), or 6-10C aryl (optionally substituted by one or more 1-6C alkyl or alkoxy, 3-11C cycloalkyl, halogen, and nitro); - Q, Q' = CR4R5, or absent; - R4 and R5 = deuterium, halogen, 1-18C alkyl (optionally substituted by one or more 1-6C alkoxy, 3-11C cycloalkyl, halogen, 6-10C aryl, and nitro), 6-10C aryl (optionally substituted by one or more 1-6C alkyl or alkoxy, 3-11C cycloalkyl, halogen, and nitro), 1-18C alkoxy (optionally substituted by one or more 1-6C alkoxy, 3-11C cycloalkyl, halogen, 6-10C aryl, and nitro), nitro, 3-11C cycloalkyl (optionally substituted by one or more 1-6C alkyl or alkoxy, halogen, and nitro); - T'1 and T'2 = 1-18C alkyl , 6-10C aryl, or OR'; and - R'1a = R' or P(O)(OR)2; - with the proviso that these compounds may not have more than two groups P(O)(OR)2
IPC 1-7
IPC 8 full level
G01N 33/84 (2006.01); C07F 9/38 (2006.01); C07F 9/40 (2006.01); C07F 9/572 (2006.01); G01N 21/80 (2006.01)
CPC (source: EP US)
C07F 9/3808 (2013.01 - EP US); C07F 9/4006 (2013.01 - EP US); C07F 9/572 (2013.01 - EP US); C07B 2200/05 (2013.01 - EP US)
Designated contracting state (EPC)
DE ES FR GB IT
DOCDB simple family (publication)
FR 2776293 A1 19990924; FR 2776293 B1 20021004; EP 1064287 A1 20010103; JP 2002506871 A 20020305; US 6528656 B1 20030304; WO 9947527 A1 19990923
DOCDB simple family (application)
FR 9803317 A 19980318; EP 99909041 A 19990318; FR 9900631 W 19990318; JP 2000536722 A 19990318; US 64643000 A 20001116