EP 1064373 A2 20010103 - IDENTIFICATION OF FACTORS WHICH MEDIATE THE INTERACTION OF HETEROTRIMERIC G PROTEINS AND MONOMERIC G PROTEINS
Title (en)
IDENTIFICATION OF FACTORS WHICH MEDIATE THE INTERACTION OF HETEROTRIMERIC G PROTEINS AND MONOMERIC G PROTEINS
Title (de)
IDENTIFIZIERUNG VON FAKTOREN, DIE DIE INTERAKTION ZWISCHEN HETEROTRIMEREN UND MONOMEREN G PROTEINEN VERMITTELN
Title (fr)
IDENTIFICATION DE FACTEURS REGULANT L'INTERACTION ENTRE DES PROTEINES G HETEROTRIMERES ET DES PROTEINES G MONOMERES
Publication
Application
Priority
- US 9906051 W 19990318
- US 7863498 P 19980318
Abstract (en)
[origin: WO9947557A2] Monomeric GTPase guanine nucleotide exchange factor (GEF) have been identified which also contain an RGS region analogous to those of GTPase activating proteins (GAP). One of these GEF proteins, a Rho GEF has been demonstrated to contain an RGS sequence that has GAP activity toward a alpha subunit of a heterotrimeric G prote in.
IPC 1-7
C12N 15/12; C07K 14/82; A61K 38/17; G01N 33/68; C12N 15/63; C12N 5/10
IPC 8 full level
C07K 14/00 (2006.01); C07K 14/47 (2006.01); C07K 14/82 (2006.01); C12N 5/10 (2006.01); C12N 9/16 (2006.01); C12N 15/09 (2006.01); C12Q 1/68 (2006.01)
CPC (source: EP)
C07K 14/4722 (2013.01); C07K 14/82 (2013.01); C12N 9/16 (2013.01)
Citation (search report)
See references of WO 9947557A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9947557 A2 19990923; WO 9947557 A3 19991118; AU 3103899 A 19991011; CA 2319037 A1 19990923; CN 1293709 A 20010502; EP 1064373 A2 20010103; JP 2002509862 A 20020402
DOCDB simple family (application)
US 9906051 W 19990318; AU 3103899 A 19990318; CA 2319037 A 19990318; CN 99804014 A 19990318; EP 99912727 A 19990318; JP 2000536748 A 19990318