Global Patent Index - EP 1064378 A2

EP 1064378 A2 2001-01-03 - HYPOXIA-INDUCIBLE HUMAN GENES, PROTEINS, AND USES THEREOF

Title (en)

HYPOXIA-INDUCIBLE HUMAN GENES, PROTEINS, AND USES THEREOF

Title (de)

DURCH HYPOXIE-INDUZIERBARE HUMANE GENE, PROTEINE UND DEREN VERWENDUNG

Title (fr)

GENES ET PROTEINES D'ORIGINE HUMAINE EXPRIMES DANS DES CONDITIONS D'HYPOXIE, ET UTILISATIONS DE CEUX-CI

Publication

EP 1064378 A2 (EN)

Application

EP 99916187 A

Priority

  • US 9906860 W
  • US 4971998 A

Abstract (en)

[origin: WO9948916A2] The polynucleotide and polypeptide sequences of two novel hypoxia-inducible human genes, HIG1 and HIG2, are described. In addition, a number of known genes have now been established as being hypoxia-inducible. These genes include annexin V, lipocortin 2, hnRNP A1, Ku autoantigen, phosphoribosylpyrophosphate synthetase, acetoacetylCoA thiolase, ribosomal L7, fibroblast growth factor-3, EPH receptor ligand, plasminogen activator inhibitor-1, macrophage migration inhibitory factor, fibronectin receptor, lysyl hydroxylase-2, endothelin-2, B-cell translocation gene-1, reducing agent and tunicamycin-responsive protein, CDC-like kinase-1, quiescin, growth arrest DNA damage-inducible protein 45, DEC1, low density lipoprotein receptor related protein, hamster hairy gene homologue, adipophilin, cyclooxygenase-1, fructose bisphosphatase, creatine transporter, fatty acid binding protein, lactate dehydrogenase, Bcl-2-interacting killer, Nip3L/Nix, and Pim-1. Polynucleotide and polypeptide arrays comprising the hypoxia-inducible gene sequences, proteins, or antibodies which specifically bind the proteins are disclosed. Methods for using the hypoxia-inducible gene sequences and proteins, and arrays thereof, to diagnose and treat hypoxia-related conditions such as cancer and ischemia are also provided.

IPC 1-7 (main, further and additional classification)

C12N 15/12; A61K 31/70; A61K 39/00; A61K 48/00; C07K 14/435; C07K 14/47; C07K 16/18; C12N 15/70; C12N 15/79; C12Q 1/68; G01N 33/577

IPC 8 full level (invention and additional information)

G01N 33/50 (2006.01); A61K 31/711 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12Q 1/68 (2006.01)

CPC (invention and additional information)

C12Q 1/6883 (2013.01); C07K 14/4702 (2013.01); C12Q 2600/158 (2013.01)

Citation (search report)

See references of WO 9948916A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9948916 A2 19990930; WO 9948916 A3 20000120; WO 9948916 A8 20080508; AU 3455599 A 19991018; CA 2322843 A1 19990930; EP 1064378 A2 20010103; JP 2002507405 A 20020312

INPADOC legal status


2004-04-07 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20031001

2001-05-02 [RIN1] INVENTOR (CORRECTION)

- Inventor name: DENKO, NICHOLAS, C.

2001-05-02 [RIN1] INVENTOR (CORRECTION)

- Inventor name: GIACCIA, AMATO, J.

2001-05-02 [RIN1] INVENTOR (CORRECTION)

- Inventor name: GREEN, CHRISTOPHER, J.

2001-05-02 [RIN1] INVENTOR (CORRECTION)

- Inventor name: LADEROUTE, KEITH, R.

2001-05-02 [RIN1] INVENTOR (CORRECTION)

- Inventor name: SCHINDLER, CORNELIA

2001-05-02 [RIN1] INVENTOR (CORRECTION)

- Inventor name: KOONG, ALBERT, CHING-WEI

2001-01-03 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000906

2001-01-03 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE