EP 1064945 A1 20010103 - Therapeutic use of a helium/oxygen mixture, especially for treating asthma

Title (en)

Therapeutic use of a helium/oxygen mixture, especially for treating asthma

Title (de)

Therapeutische Verwendung eines Helium/Oxygen Gemisches, insbesondere für die Behandlung von Asthma

Title (fr)

Utilisations thérapeutiques d'un mélange helium/oxygene, en particulier dans le traitement de l'asthme

Publication

EP 1064945 A1 20010103 (FR)

Application

EP 00401750 A 20000620

Priority

FR 9908563 A 19990702

Abstract (en)

Ready to use gaseous mixtures of 63.1 - 69.9% by volume of helium, the balance being oxygen, at a pressure of at least 2 bars, and the use of such mixtures as aerosol propellants for the administration of medicaments. The mixture is preferably 65% by volume of helium and 35% oxygen, at a pressure of 2 - 300 bars, especially 100 - 250 bars. The gases may be used to make aerosols for the administration of beta 2-mimetics, corticoids, and anticholinergic agents. Independent claims are also included for gas bottles containing the gaseous mixture and installations for the administration of the mixture to patients comprising a gas bottle, a respiratory assistance ventilator, and tubing to connect these.

Abstract (fr)

L'invention concerne un mélange gazeux binaire prêt à l'emploi contenant de 63.1 à 69.9 % en volume d'hélium et le reste étant de l'oxygène, de préférence un mélange de 65% d'hélium et de 35% d'oxygène, et son utilisation dans le traitement de l'asthme, des broncho-pneumopathies obstructives ou analogues. Un tel mélange gazeux peut être utilisé en tant que gaz vecteur ou propulseur d'aérosols médicamenteux, en particulier d'aérosols contenant une substance thérapeutiquement efficace choisie parmi les β2-mimétiques, les corticoïdes et les anticholinergiques.

IPC 1-7

A61K 33/00; A61M 16/00; A62B 9/00; B63C 11/00; A62B 7/00; A61P 11/00; A61P 11/06; A61K 47/02

IPC 8 full level

A61K 47/02 (2006.01); A61K 9/00 (2006.01); A61K 9/12 (2006.01); A61K 9/14 (2006.01); A61K 9/72 (2006.01); A61K 31/137 (2006.01); A61K 31/573 (2006.01); A61K 33/00 (2006.01); A61K 45/00 (2006.01); A61L 9/04 (2006.01); A61M 16/00 (2006.01); A61M 16/10 (2006.01); A61M 16/12 (2006.01); A61P 11/00 (2006.01); A61P 11/06 (2006.01); A61P 11/08 (2006.01); A61P 11/16 (2006.01)

CPC (source: EP US)

A61K 9/008 (2013.01 - EP US); A61K 9/124 (2013.01 - EP US); A61K 33/00 (2013.01 - EP US); A61P 11/00 (2018.01 - EP); A61P 11/06 (2018.01 - EP); A61P 11/08 (2018.01 - EP); A61P 11/16 (2018.01 - EP)

C-Set (source: EP US)

Citation (search report)

[A] US 3682165 A 19720808 - EKLUND ERIK
[A] US 3815591 A 19740611 - SCHREINER H, et al
[DY] EP 0727219 A2 19960821 - BOC GROUP PLC [GB]
[DXA] EP 0639378 A1 19950222 - MESSER GRIESHEIM AUSTRIA GES M [AT]
[X] WO 9516484 A1 19950622 - UNIV TEMPLE [US]
[X] US 5228434 A 19930720 - FISHMAN ROYCE S [US]
[DX] WO 9520411 A1 19950803 - AGA AB [SE], et al
[Y] EP 0244285 A1 19871104 - AIR LIQUIDE [FR]
[X] WO 9842383 A1 19981001 - IMARX PHARMACEUTICAL CORP [US]
[X] US 5542935 A 19960806 - UNGER EVAN C [US], et al
[A] US 5570683 A 19961105 - ZAPOL WARREN M [US]
[DA] EP 0868921 A2 19981007 - BOC GROUP PLC [GB]
[XA] CHOUX C ET AL: "Helium-oxygen mixture: Pre-hospitalization care of acute asthma: Prospective study: SAMU 69 (October 1991-December 1992)", URGENCES MEDICALES,FR,PARIS, XP002074498, ISSN: 0923-2524
[X] GLUCK E H ET AL: "HELIUM-OXYGEN MIXTURES IN INTUBATED PATIENTS WITH STATUS ASTHMATICUS AND RESPIRATORY ACIDOSIS", CHEST,US,PARK RIDGE, IL, vol. 98, no. 3, 1 September 1990 (1990-09-01), pages 693 - 698, XP002074496

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

EP 1064945 A1 20010103; EP 1064945 B1 20020814; AT E222110 T1 20020815; AU 4378100 A 20010104; AU 771976 B2 20040408; CA 2314173 A1 20010102; CA 2314173 C 20090303; DE 60000325 D1 20020919; DE 60000325 T2 20030313; ES 2181630 T3 20030301; FR 2795644 A1 20010105; FR 2795644 B1 20040730; JP 2001055337 A 20010227; PT 1064945 E 20021129; US 6592848 B1 20030715; ZA 200003148 B 20010305

DOCDB simple family (application)

EP 00401750 A 20000620; AT 00401750 T 20000620; AU 4378100 A 20000630; CA 2314173 A 20000629; DE 60000325 T 20000620; ES 00401750 T 20000620; FR 9908563 A 19990702; JP 2000198810 A 20000630; PT 00401750 T 20000620; US 60937200 A 20000703; ZA 200003148 A 20000622