EP 1064951 B1 20070822 - Erythropoietin derivatives
Title (en)
Erythropoietin derivatives
Title (de)
Erythropoietin Derivate
Title (fr)
Dérivés de l' Erythropoietine
Publication
Application
Priority
- US 14225499 P 19990702
- US 15022599 P 19990823
- US 15154899 P 19990831
- US 16615199 P 19991117
Abstract (en)
[origin: EP1064951A2] The present invention refers to conjugates of erythropoietin with poly(ethylene glycol) comprising an erythropoietin glycoprotein having at least one free amino group and having the in vivo biological activity of causing bone marrow cells to increase production of reticulocytes and red blood cells and selected from the group consisting of human erythropoietin and analogs thereof which have sequence of human erythropoietin modified by the addition of from 1 to 6 glycosylation sites or a rearrangement of at least one glycosylation site; said glycoprotein being covalently linked to "n" poly(ethylene glycol) groups of the formula -CO-(CH2)x(OCH2CH2)m-OR with the carbonyl of each poly(ethylene glycol) group forming an amide bond with one of said amino groups; wherein R is lower alkyl; x is 2 or 3; m is about 450 to about 900; n is from 1 to 3; and n and m are chosen so that the molecular weight of the conjugate minus the erythropoietin glycoprotein is from 20 kilodaltons to 100 kilodaltons.
IPC 8 full level
A61K 47/48 (2006.01); A61K 38/00 (2006.01); A61K 38/22 (2006.01); A61P 7/00 (2006.01); A61P 7/06 (2006.01); A61P 13/12 (2006.01); A61P 31/18 (2006.01); A61P 35/00 (2006.01); C07K 1/107 (2006.01); C07K 14/505 (2006.01); C07K 14/59 (2006.01); C07K 17/08 (2006.01); C07K 19/00 (2006.01); C12N 15/12 (2006.01)
CPC (source: EP KR US)
A61K 47/60 (2017.08 - EP US); A61K 47/62 (2017.08 - EP US); A61P 7/00 (2018.01 - EP); A61P 7/06 (2018.01 - EP); A61P 13/12 (2018.01 - EP); A61P 25/18 (2018.01 - EP); A61P 31/00 (2018.01 - EP); A61P 31/18 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 37/00 (2018.01 - EP); C07K 14/505 (2013.01 - EP KR US); C07K 17/08 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated extension state (EPC)
AL LT LV MK RO SI
DOCDB simple family (publication)
EP 1064951 A2 20010103; EP 1064951 A3 20020320; EP 1064951 B1 20070822; AR 024625 A1 20021016; AR 055650 A2 20070829; AT E370748 T1 20070915; AU 4274400 A 20010104; AU 736067 B2 20010726; BG 104570 A 20010928; BG 65449 B1 20080829; BR 0002276 A 20011211; BR PI0002276 B1 20190514; BR PI0002276 B8 20210525; CA 2310536 A1 20010102; CA 2310536 C 20070911; CN 1184233 C 20050112; CN 1280137 A 20010117; CN 1283664 C 20061108; CN 1515590 A 20040728; CO 5190661 A1 20020829; CY 1107719 T1 20100728; CY 2007021 I1 20091104; CY 2007021 I2 20091104; CZ 20002386 A3 20020417; CZ 299516 B6 20080820; DE 10031839 A1 20010201; DE 122007000064 I1 20080103; DE 122007000064 I2 20100325; DE 60036053 D1 20071004; DE 60036053 T2 20080103; DK 1064951 T3 20071008; DO P2000000030 A 20020715; EA 003777 B1 20030828; EA 200000607 A1 20010226; EP 1839676 A2 20071003; EP 1839676 A3 20080903; ES 2191511 A1 20030901; ES 2191511 B1 20050101; ES 2289985 T3 20080216; FR 07C0051 I1 20071214; FR 07C0051 I2 20080509; FR 2795734 A1 20010105; FR 2795734 B1 20050930; GB 0016205 D0 20000823; GB 0400086 D0 20040204; GB 2353281 A 20010221; GB 2353281 B 20040609; GB 2393960 A 20040414; GB 2393960 B 20040804; GB 2393960 C 20120829; GC 0000197 A 20060329; GE P20022804 B 20020925; GT 200000109 A 20011221; HK 1033328 A1 20010824; HK 1068354 A1 20050429; HR P20000436 A2 20010630; HR P20000436 B1 20080131; HU 0002553 D0 20000828; HU 226233 B1 20080728; HU P0002553 A2 20010328; HU P0002553 A3 20051128; ID 26447 A 20010104; IL 137056 A0 20010614; IS 2492 B 20090215; IS 5554 A 20010102; IT 1318606 B1 20030827; IT MI20001479 A0 20000630; IT MI20001479 A1 20011230; JP 2001064300 A 20010313; JP 2004155787 A 20040603; JP 3727009 B2 20051214; KR 100593143 B1 20060626; KR 20010049676 A 20010615; LU 91363 I2 20071112; LU 91363 I9 20181231; MA 26746 A1 20041220; MX PA00006547 A 20041028; MY 128500 A 20070228; NL 300289 I1 20071101; NL 300289 I2 20100201; NL 300289 I9 20190821; NO 20003372 D0 20000628; NO 20003372 L 20010103; NO 2009010 I1 20090525; NO 2009010 I2 20140602; NO 327043 B1 20090406; NZ 505454 A 20011221; OA 11442 A 20040428; PA 8497801 A1 20011214; PE 20010297 A1 20010307; PL 202758 B1 20090731; PL 341187 A1 20010115; PT 1064951 E 20070910; RS 49928 B 20080929; SG 92717 A1 20021119; SI 1064951 T1 20071231; SK 286301 B6 20080707; SK 9872000 A3 20020604; SV 2002000120 A 20020131; TN SN00147 A1 20051110; TR 200001956 A2 20010122; TW I235667 B 20050711; US 2003120045 A1 20030626; US 6583272 B1 20030624; UY 26228 A1 20001031; YU 40700 A 20031231
DOCDB simple family (application)
EP 00113115 A 20000628; AR P000103318 A 20000629; AR P060104175 A 20060925; AT 00113115 T 20000628; AU 4274400 A 20000628; BG 10457000 A 20000630; BR 0002276 A 20000703; BR PI0002276 A 20000703; CA 2310536 A 20000628; CN 00107889 A 20000629; CN 200410003602 A 20000629; CO 00048963 A 20000629; CY 071101097 T 20070823; CY 2007021 C 20070906; CZ 20002386 A 20000623; DE 10031839 A 20000630; DE 122007000064 C 20000628; DE 60036053 T 20000628; DK 00113115 T 20000628; DO 2000000030 A 20000628; EA 200000607 A 20000703; EP 07010693 A 20000628; ES 00113115 T 20000628; ES 200001625 A 20000630; FR 0008609 A 20000703; FR 07C0051 C 20071019; GB 0016205 A 20000630; GB 0400086 A 20000630; GC P2000749 A 20000702; GE AP2000005430 A 20000629; GT 200000109 A 20000629; HK 01104020 A 20010612; HK 05100477 A 20010612; HR P20000436 A 20000628; HU P0002553 A 20000630; ID 20000533 D 20000628; IL 13705600 A 20000628; IS 5554 A 20000630; IT MI20001479 A 20000630; JP 2000201525 A 20000703; JP 2003419520 A 20031217; KR 20000036976 A 20000630; LU 91363 C 20070912; MA 26014 A 20000630; MX PA00006547 A 20000630; MY PI20002954 A 20000629; NL 300289 C 20070905; NO 20003372 A 20000628; NO 2009010 C 20090505; NZ 50545400 A 20000628; OA 1200000197 A 20000630; PA 8497801 A 20000629; PE 0006542000 A 20000628; PL 34118700 A 20000703; PT 00113115 T 20000628; SG 200003658 A 20000629; SI 200030963 T 20000628; SK 9872000 A 20000627; SV 2000000120 A 20000630; TN SN00147 A 20000630; TR 200001956 A 20000628; TW 89112948 A 20000630; US 29355102 A 20021114; US 60493800 A 20000627; UY 26228 A 20000630; YU P40700 A 20000628