EP 1066295 A2 20010110 - SYNTHESIS OF COMPOUNDS AND LIBRARIES OF COMPOUNDS
Title (en)
SYNTHESIS OF COMPOUNDS AND LIBRARIES OF COMPOUNDS
Title (de)
SYNTHESE VON VERBINDUNGEN UND SUBSTANZBIBLIOTHEKEN
Title (fr)
SYNTHESE DE COMPOSES ET DE BANQUES DE COMPOSES
Publication
Application
Priority
- US 9906233 W 19990322
- US 7903598 P 19980323
Abstract (en)
[origin: WO9948897A2] The present invention provides a system for the production of chemical compounds and libraries of compounds that are complex, stereochemically and regioselectively pure, and may mimic the structural or functional properties of a peptide. The invention provides methods for producing collections of peptidomimetic compounds which, in one preferred embodiment, comprises (1) providing two diversifiable monomers containing terminal reactive moieties; (2) reacting the monomers under conditions that allow for the control of stereochemistry as well as chemoselectivity; and (3) generating diversifiable isolable compounds or libraries of compounds. In another preferred embodiment, a collection of peptidomimetic compounds is provided by (1) providing at least one diversifiable monomer containing terminal reactive moieties; (2) reacting the monomer with a reagent under conditions that allow for the control of stereochemistry as well as chemoselectivity; and (3) generating diversifiable isolable compounds or libraries of compounds. In another broader aspect, the present invention provides for the synthesis of a collection of compounds comprising peptidomimetics and non-peptidomimetics alike having stereodiversity. This method involves the steps of (1) selecting desired synthetic precursors having a predefined stereochemical relationship; (2) reacting the synthetic precursors so that a compound having a specific stereochemistry is obtained; and (3) repeating these steps of selecting and reacting until a desired library of compounds having stereochemical diversity is obtained. In certain preferred embodiments, a library of compounds having only diversity of stererochemistry is provided. In certain other preferred embodiments, a library of compounds having structural diversity and stereochemical diversity is provided. The present invention also provides various chemical compounds useful in the inventive methods for production of complex peptidomimetic libraries. The peptidomimetic and stereodiverse compounds of the inventive method are useful for interactions with receptors in cells and may emulate the structure and functionality of peptides.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); C07B 61/00 (2006.01); C07C 271/16 (2006.01); C07C 327/22 (2006.01); C07D 207/16 (2006.01); C07D 223/10 (2006.01); C07D 263/22 (2006.01); C07F 7/18 (2006.01); C07F 9/6574 (2006.01); C07K 1/00 (2006.01); C07K 1/04 (2006.01); C40B 40/02 (2006.01); C40B 40/04 (2006.01); C40B 40/16 (2006.01); C40B 50/00 (2006.01); C40B 50/06 (2006.01)
CPC (source: EP)
C07C 271/16 (2013.01); C07D 207/16 (2013.01); C07D 223/10 (2013.01); C07D 263/22 (2013.01); C07F 9/65742 (2013.01); C07K 1/047 (2013.01); C07B 2200/11 (2013.01); C40B 40/00 (2013.01)
Citation (search report)
See references of WO 9948897A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9948897 A2 19990930; WO 9948897 A3 19991111; WO 9948897 B1 20000120; CA 2324016 A1 19990930; EP 1066295 A2 20010110; HU P0103260 A2 20020228; HU P0103260 A3 20020328; IL 138647 A0 20011031; IL 138647 A 20061031; JP 2002507617 A 20020312
DOCDB simple family (application)
US 9906233 W 19990322; CA 2324016 A 19990322; EP 99912805 A 19990322; HU P0103260 A 19990322; IL 13864700 A 20000922; IL 13864799 A 19990322; JP 2000537880 A 19990322