EP 1066320 A1 20010110 - ORPHAN NUCLEAR RECEPTOR
Title (en)
ORPHAN NUCLEAR RECEPTOR
Title (de)
ZELLKERN WAISENREZEPTOR
Title (fr)
RECEPTEUR NUCLEAIRE ORPHELIN
Publication
Application
Priority
- US 9906737 W 19990326
- US 7959398 P 19980327
Abstract (en)
[origin: WO9948915A1] The present invention relates to a novel human orphan nuclear receptor that binds to a cytochrome P-450 monooxygenase (CYP) promoter and that is activated by compounds that induce CYP gene expression. The invention further relates to nucleic acid sequences encoding such a receptor, to methods of making the receptor and to methods of using the receptor and nucleic acid sequences encoding same. The invention also relates to non-human animals transformed to express the human receptor and to methods of using such animals to screen compounds for drug interactions and toxicities.
IPC 1-7
C07K 14/00; C07K 14/435; C07K 14/705; C12N 5/16; C12N 15/12; C12N 15/62; C12N 15/63; G01N 33/53; G01N 33/566
IPC 8 full level
C07K 14/00 (2006.01); C07K 14/435 (2006.01); C07K 14/705 (2006.01); C07K 19/00 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12Q 1/68 (2006.01); C12Q 1/6897 (2018.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/566 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 14/70567 (2013.01); C12Q 1/6897 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9948915 A1 19990930; WO 9948915 A9 19991118; AU 3211699 A 19991018; EP 1066320 A1 20010110; EP 1066320 A4 20050316; JP 2002535241 A 20021022
DOCDB simple family (application)
US 9906737 W 19990326; AU 3211699 A 19990326; EP 99914221 A 19990326; JP 2000537897 A 19990326