Global patent index - EP 1066377 A1

EP 1066377 A1 2001-01-10 - METHODS FOR PREVENTION AND TREATMENT OF CANCER

Title (en)

METHODS FOR PREVENTION AND TREATMENT OF CANCER

Title (de)

METHODEN ZUR PRÄVENTION UND BEHANDLUNG VON KREBS

Title (fr)

METHODES DE PREVENTION ET DE TRAITEMENT DU CANCER

Publication

EP 1066377 A1 (EN)

Application

EP 99915026 A

Priority

  • US 9906491 W
  • US 4791898 A
  • US 12227099 P
  • US 12226899 P
  • US 12366999 P
  • US 12367099 P

Abstract (en)

[origin: WO9949027A1] Methods for inhibiting cancer cell growth are disclosed. In one embodiment, the method comprises the step of increasing the amount of a metabolic precursor of 1,25-dihydroxyvitamin D ("1,25(OH)2)D") or an analog or a derivative thereof available to a target cell. In a preferred embodiment, the precursor is 25-hydroxyvitamin D. In another embodiment, the method comprises administering a gene coding for 25-hydroxyvitamin D-1 alpha -hydroxylase ("1 alpha -OHase") with or without a gene coding for the vitamin D receptor to the target cell to increase production of 1,25(OH)2D or analog thereof within the target cell, thereby inhibiting cellular proliferation. In another embodiment of the invention, the method of administering a gene coding for 1 alpha -OHase with or without a gene coding for the vitamin D receptor to a target cell or tissue is used in the treatment of hyperproliferative cell disorders, disorders of hair growth, and disorders of calcium and bone metabolism in animals.

IPC 1-7 (main, further and additional classification)

C12N 15/09; A61K 35/00; A61K 38/43; A61K 48/00; C12N 15/11; C12N 15/63

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 31/59 (2006.01); A61K 35/00 (2006.01); A61K 38/43 (2006.01); A61K 38/44 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 3/10 (2006.01); A61P 13/08 (2006.01); A61P 17/02 (2006.01); A61P 17/06 (2006.01); A61P 17/14 (2006.01); A61P 19/08 (2006.01); A61P 25/00 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C12N 9/08 (2006.01); C12N 9/12 (2006.01)

CPC (invention and additional information)

C12N 9/0065 (2013.01); A61K 31/59 (2013.01); A61K 38/44 (2013.01); C12Y 114/13126 (2013.01); A61K 48/00 (2013.01)

Citation (search report)

See references of WO 9949027A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9949027 A1 19990930; CA 2323782 A1 19990930; CN 1301298 A 20010627; EP 1066377 A1 20010110; JP 2002507415 A 20020312

INPADOC legal status

2003-06-18 [18W] WITHDRAWN

- Ref Legal Event Code: 18W

- Effective date: 20030416

2001-01-10 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20001024

2001-01-10 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE