EP 1066377 A1 20010110 - METHODS FOR PREVENTION AND TREATMENT OF CANCER
Title (en)
METHODS FOR PREVENTION AND TREATMENT OF CANCER
Title (de)
METHODEN ZUR PRÄVENTION UND BEHANDLUNG VON KREBS
Title (fr)
METHODES DE PREVENTION ET DE TRAITEMENT DU CANCER
Publication
Application
Priority
- US 9906491 W 19990325
- US 4791898 A 19980325
- US 12227099 P 19990301
- US 12226899 P 19990301
- US 12366999 P 19990309
- US 12367099 P 19990309
Abstract (en)
[origin: WO9949027A1] Methods for inhibiting cancer cell growth are disclosed. In one embodiment, the method comprises the step of increasing the amount of a metabolic precursor of 1,25-dihydroxyvitamin D ("1,25(OH)2)D") or an analog or a derivative thereof available to a target cell. In a preferred embodiment, the precursor is 25-hydroxyvitamin D. In another embodiment, the method comprises administering a gene coding for 25-hydroxyvitamin D-1 alpha -hydroxylase ("1 alpha -OHase") with or without a gene coding for the vitamin D receptor to the target cell to increase production of 1,25(OH)2D or analog thereof within the target cell, thereby inhibiting cellular proliferation. In another embodiment of the invention, the method of administering a gene coding for 1 alpha -OHase with or without a gene coding for the vitamin D receptor to a target cell or tissue is used in the treatment of hyperproliferative cell disorders, disorders of hair growth, and disorders of calcium and bone metabolism in animals.
IPC 1-7
C12N 15/09; C12N 15/11; C12N 15/63; A61K 48/00; A61K 35/00; A61K 38/43
IPC 8 full level
A61K 31/59 (2006.01); A61K 35/00 (2006.01); A61K 38/43 (2006.01); A61K 38/44 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 3/10 (2006.01); A61P 13/08 (2006.01); A61P 17/02 (2006.01); A61P 17/06 (2006.01); A61P 17/14 (2006.01); A61P 19/08 (2006.01); A61P 25/00 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C12N 9/08 (2006.01); C12N 9/12 (2006.01); C12N 15/09 (2006.01)
CPC (source: EP)
A61K 31/59 (2013.01); A61K 38/44 (2013.01); A61P 3/10 (2017.12); A61P 13/08 (2017.12); A61P 17/02 (2017.12); A61P 17/06 (2017.12); A61P 17/14 (2017.12); A61P 19/08 (2017.12); A61P 25/00 (2017.12); A61P 29/00 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C12N 9/0065 (2013.01); C12Y 114/13126 (2013.01); A61K 48/00 (2013.01)
Citation (search report)
See references of WO 9949027A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9949027 A1 19990930; CA 2323782 A1 19990930; CN 1301298 A 20010627; EP 1066377 A1 20010110; JP 2002507415 A 20020312
DOCDB simple family (application)
US 9906491 W 19990325; CA 2323782 A 19990325; CN 99806417 A 19990325; EP 99915026 A 19990325; JP 2000537988 A 19990325