Global Patent Index - EP 1066378 A2

EP 1066378 A2 2001-01-10 - LYST PROTEIN COMPLEXES AND LYST INTERACTING PROTEINS

Title (en)

LYST PROTEIN COMPLEXES AND LYST INTERACTING PROTEINS

Title (de)

LYST PROTEINKOMPLEXE UND MIT LYST INTERAGIERENDE PROTEINE

Title (fr)

COMPLEXES DE PROTEINE LYST ET PROTEINES A INTERACTION LYST

Publication

EP 1066378 A2 (EN)

Application

EP 99914251 A

Priority

  • US 9906831 W
  • US 5495698 A

Abstract (en)

[origin: WO9951741A2] The present invention relates to complexes of the LYST or LYST-2 protein with proteins identified as interacting with LYST or LYST-2 by a modified yeast two hybrid assay system. The proteins identified to interact with LYST or LYST-2 are 14-3-3 protein, HS1 protein, Hrs, BMK1, KB07, Efs, XAP-4, OS9, casein kinase II beta SU, calmodulin, troponin I, importin beta, Fte-1, hERR1, imogen 38, atrophin-1, norbin, HBF-G2, DGS-I, GBDR1, OPA containing protein, M4 protein, LIP1, LIP2, LIP3, LIP4, LIP5, LIP6, LIP7, LIP8, LIP9 and LIP10. Thus, the invention provides complexes of LYST or LYST-2 and 14-3-3 protein, HS1 protein, Hrs, BMK1, KB07, Efs, XAP-4, OS9, casein kinase II beta SU, calmodulin, troponin I, importin beta, Fte-1, hERR1, imogen 38, atrophin-1, norbin, HBF-G2, DGS-I, GBDR1, OPA containing protein, M4 protein, LIP1, LIP2, LIP3, LIP4, LIP5, LIP6, LIP7, LIP8, LIP9 and LIP10, and derivatives, fragments and analogs thereof. The invention also provides nucleic acis encoding the LIP1, LIP2, LIP3, LIP4, LIP5, LIP6, LIP7, LIP8, LIP9, and LIP10 protein, or derivatives, fragments and analogs thereof. Methods of screening the complexes or proteins for efficacy in treating and/or preventing certain diseases and disorders, particularly atopic diseases, autoimmune diseases, neurodegenerative disease, cancer, pigmentation disorders, platelet dysfunction and viral diseases, are also provided.

IPC 1-7 (main, further and additional classification)

C12N 15/12; A01K 67/027; A61K 38/17; C07K 14/47; C07K 16/18; C07K 19/00; C12N 5/10; C12N 15/62; C12Q 1/68

IPC 8 full level (invention and additional information)

A01K 67/027 (2006.01); A61K 38/00 (2006.01); A61P 7/02 (2006.01); A61P 7/04 (2006.01); A61P 17/00 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 37/02 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C07K 19/00 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/12 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12Q 1/68 (2006.01); G01N 33/68 (2006.01)

CPC (invention and additional information)

C12N 9/1205 (2013.01); C07K 14/47 (2013.01); C07K 14/4716 (2013.01); C07K 14/4728 (2013.01); A01K 2217/05 (2013.01); A01K 2217/075 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01)

Citation (search report)

See references of WO 9951741A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9951741 A2 19991014; WO 9951741 A3 19991223; AU 3214099 A 19991025; CA 2325562 A1 19991014; EP 1066378 A2 20010110; JP 2002510490 A 20020409

INPADOC legal status


2005-04-13 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20041001

2001-01-10 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20001027

2001-01-10 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE