EP 1066378 A2 20010110 - LYST PROTEIN COMPLEXES AND LYST INTERACTING PROTEINS
Title (en)
LYST PROTEIN COMPLEXES AND LYST INTERACTING PROTEINS
Title (de)
LYST PROTEINKOMPLEXE UND MIT LYST INTERAGIERENDE PROTEINE
Title (fr)
COMPLEXES DE PROTEINE LYST ET PROTEINES A INTERACTION LYST
Publication
Application
Priority
- US 9906831 W 19990329
- US 5495698 A 19980403
Abstract (en)
[origin: WO9951741A2] The present invention relates to complexes of the LYST or LYST-2 protein with proteins identified as interacting with LYST or LYST-2 by a modified yeast two hybrid assay system. The proteins identified to interact with LYST or LYST-2 are 14-3-3 protein, HS1 protein, Hrs, BMK1, KB07, Efs, XAP-4, OS9, casein kinase II beta SU, calmodulin, troponin I, importin beta, Fte-1, hERR1, imogen 38, atrophin-1, norbin, HBF-G2, DGS-I, GBDR1, OPA containing protein, M4 protein, LIP1, LIP2, LIP3, LIP4, LIP5, LIP6, LIP7, LIP8, LIP9 and LIP10. Thus, the invention provides complexes of LYST or LYST-2 and 14-3-3 protein, HS1 protein, Hrs, BMK1, KB07, Efs, XAP-4, OS9, casein kinase II beta SU, calmodulin, troponin I, importin beta, Fte-1, hERR1, imogen 38, atrophin-1, norbin, HBF-G2, DGS-I, GBDR1, OPA containing protein, M4 protein, LIP1, LIP2, LIP3, LIP4, LIP5, LIP6, LIP7, LIP8, LIP9 and LIP10, and derivatives, fragments and analogs thereof. The invention also provides nucleic acis encoding the LIP1, LIP2, LIP3, LIP4, LIP5, LIP6, LIP7, LIP8, LIP9, and LIP10 protein, or derivatives, fragments and analogs thereof. Methods of screening the complexes or proteins for efficacy in treating and/or preventing certain diseases and disorders, particularly atopic diseases, autoimmune diseases, neurodegenerative disease, cancer, pigmentation disorders, platelet dysfunction and viral diseases, are also provided.
IPC 1-7
C12N 15/12; C07K 14/47; C12N 15/62; C07K 16/18; C12N 5/10; A61K 38/17; C12Q 1/68; A01K 67/027; C07K 19/00
IPC 8 full level
A01K 67/027 (2006.01); A61K 38/00 (2006.01); A61P 7/02 (2006.01); A61P 7/04 (2006.01); A61P 17/00 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 37/02 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C07K 19/00 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/12 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12Q 1/68 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
A61P 7/02 (2017.12); A61P 7/04 (2017.12); A61P 17/00 (2017.12); A61P 31/12 (2017.12); A61P 35/00 (2017.12); A61P 37/02 (2017.12); C07K 14/47 (2013.01); C07K 14/4716 (2013.01); C07K 14/4728 (2013.01); C12N 9/1205 (2013.01); A01K 2217/05 (2013.01); A01K 2217/075 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01)
Citation (search report)
See references of WO 9951741A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9951741 A2 19991014; WO 9951741 A3 19991223; AU 3214099 A 19991025; CA 2325562 A1 19991014; EP 1066378 A2 20010110; JP 2002510490 A 20020409
DOCDB simple family (application)
US 9906831 W 19990329; AU 3214099 A 19990329; CA 2325562 A 19990329; EP 99914251 A 19990329; JP 2000542454 A 19990329