Title (en)

AMINOALKYL SUBSTITUTED 9H-PYRIDINO 2,3-b INDOLE AND 9H-PYRIMIDINO 4,5-b INDOLE DERIVATIVES

Title (de)

AMINOALKYL SUBSTITUIERTE 9H-PYRIDINO¬2,3-B INDOL- UND 9H-PYRIMIDINO¬4,5-B INDOL-DERIVATE

Title (fr)

DERIVES AMINOALKYLE SUBSTITUES DE 9H-PYRIDINO 2,3-b INDOLE ET 9H-PYRIMIDINO 4,5-b INDOLE

Publication

EP 1068207 A1 20010117 (EN)

Application

EP 99916294 A 19990401

Priority

• US 9907254 W 19990401
• US 8045198 P 19980402

Abstract (en)

[origin: WO9951600A1] Disclosed are compounds of formula (I), wherein Ar, R<1>, W and X are substituents as defined herein, which compounds are (1) antagonists at CRF1 receptors and are, therefore, useful in the diagnosis and treatment of stress related disorders such as post traumatic stress disorder (PTSD) as well as depression, headache and anxiety; and (2) are neuropeptide Y1 receptor antagonists, and are therefore useful in the treatment of a variety of clinical conditions which are characterized by the presence of an excess of neuropeptide Y.

IPC 1-7

C07D 471/04; C07D 487/04; A61K 31/435; A61K 31/505

IPC 8 full level

A61K 31/437 (2006.01); A61K 31/519 (2006.01); A61P 1/00 (2006.01); A61P 1/04 (2006.01); A61P 3/04 (2006.01); A61P 3/06 (2006.01); A61P 3/10 (2006.01); A61P 9/00 (2006.01); A61P 15/00 (2006.01); A61P 25/00 (2006.01); A61P 25/06 (2006.01); A61P 25/08 (2006.01); A61P 25/20 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 25/30 (2006.01); A61P 25/32 (2006.01); A61P 29/00 (2006.01); A61P 31/18 (2006.01); A61P 37/04 (2006.01); A61P 37/06 (2006.01); A61P 43/00 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01)

CPC (source: EP)

A61P 1/00 (2017.12); A61P 1/04 (2017.12); A61P 3/04 (2017.12); A61P 3/06 (2017.12); A61P 3/10 (2017.12); A61P 9/00 (2017.12); A61P 15/00 (2017.12); A61P 25/00 (2017.12); A61P 25/06 (2017.12); A61P 25/08 (2017.12); A61P 25/20 (2017.12); A61P 25/22 (2017.12); A61P 25/24 (2017.12); A61P 25/28 (2017.12); A61P 25/30 (2017.12); A61P 25/32 (2017.12); A61P 29/00 (2017.12); A61P 31/18 (2017.12); A61P 37/04 (2017.12); A61P 37/06 (2017.12); A61P 43/00 (2017.12); C07D 471/04 (2013.01); C07D 487/04 (2013.01)

Citation (search report)

See references of WO 9951600A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

Designated extension state (EPC)

AL LT LV MK RO SI

DOCDB simple family (publication)

WO 9951600 A1 19991014; AU 3464599 A 19991025; CA 2326606 A1 19991014; EP 1068207 A1 20010117; JP 2002510688 A 20020409

DOCDB simple family (application)

US 9907254 W 19990401; AU 3464599 A 19990401; CA 2326606 A 19990401; EP 99916294 A 19990401; JP 2000542321 A 19990401