Global Patent Index - EP 1068234 A2

EP 1068234 A2 2001-01-17 - POLYPEPTIDE DOMAINS CAPABLE OF BINDING RHO PROTEIN AND THEIR USE IN ASSAYS

Title (en)

POLYPEPTIDE DOMAINS CAPABLE OF BINDING RHO PROTEIN AND THEIR USE IN ASSAYS

Title (de)

POLYPEPTIDDOMÄNE DIE MIT RHO PROTEIN BINDEFÄHIG SIND UND IHRE VERWENDUNG IN ASSAYS

Title (fr)

DOMAINES POLYPEPTIDIQUES CAPABLES DE SE FIXER AUX PROTEINES RHO ET LEUR UTILISATION DANS DES ANALYSES

Publication

EP 1068234 A2 (EN)

Application

EP 99915903 A

Priority

  • GB 9901096 W
  • GB 9807848 A

Abstract (en)

[origin: WO9952941A2] The Rho family of GTPases are involved in a wide range of eukaryotic cellular processes. Several known effector proteins bind to these GTPases and mediate their effect. Such proteins include ROCK-I/p160ROCK, ROCK II and Kinectin. The present invention provides a novel twenty three amino acid Rho-binding region which is conserved in a range of Rho binding proteins. Other proteins, including the yeast protein Skn7, are shown to contain regions homologous to this conserved region and to interact with Rho GTPases. Assays are also provided to identify molecules which affect cell growth through modulation of the Rho GTPase/effector protein interaction.

IPC 1-7 (main, further and additional classification)

C07K 14/47; C12Q 1/48; G01N 33/573

IPC 8 full level (invention and additional information)

C07K 14/475 (2006.01)

CPC (invention and additional information)

C07K 14/475 (2013.01); C07K 2319/00 (2013.01)

Citation (search report)

See references of WO 9952941A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9952941 A2 19991021; WO 9952941 A3 19991202; WO 9952941 B1 20000106; AU 3432699 A 19991101; EP 1068234 A2 20010117; GB 9807848 D0 19980610

INPADOC legal status


2003-05-28 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20021101

2001-01-17 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20001108

2001-01-17 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE