EP 1069827 A1 20010124 - NUCLEIC ACIDS ENCODING OUTER MEMBRANE PROTEIN OF HUMAN GRANULOCYTIC EHRLICHIOSIS AGENT
Title (en)
NUCLEIC ACIDS ENCODING OUTER MEMBRANE PROTEIN OF HUMAN GRANULOCYTIC EHRLICHIOSIS AGENT
Title (de)
DIE ÄUSSEREN MEMBRANPROTEINE DES HUMANEN GRANULCYTISCHEN EHRLICHIOSE-AGENS KODIERENDEN NUKLEINSÄUREN
Title (fr)
ACIDES NUCLEIQUES CODANT UNE PROTEINE DE MEMBRANE EXTERIEURE D'AGENT D'EHRLICHIOSE GRANULOCYTAIRE HUMAINE
Publication
Application
Priority
- US 9907759 W 19990408
- US 8119298 P 19980409
- US 12808799 P 19990407
Abstract (en)
[origin: WO9952370A1] The invention provides tools for serodiagnosing HGE. The tools are structurally related proteins, "Group 44 proteins", and antibodies to such proteins. The Group 44 proteins comprise a single central hypervariable region, a first conserved region and a second conserved region which flank the central hypervariable region. The Group 44 proteins comprise P44, P44-2, P44-12, P44-15, P44-18, P44-19, and variants of such proteins. The invention also provides isolated polynucleotides or nucleic acids, referred to as "Group 44 polynucleotides", which encode the Group 44 proteins and fragments thereof. Each oligopeptide comprises a sequence specific to one Group 44 protein. The present invention also provides antibodies immunospecific for and which bind to members of the P44 family of proteins. The present invention provides kits containing reagent for diagnosing HGE.
IPC 1-7
A01N 63/00; A61K 38/00; A61K 39/02; A61K 39/40; C07H 21/04; C07K 1/00; C07K 16/00; G01N 33/53
IPC 8 full level
C07K 16/12 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
C07K 16/1246 (2013.01); G01N 33/6893 (2013.01); G01N 2333/43556 (2013.01); G01N 2469/20 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9952370 A1 19991021; AU 3483599 A 19991101; CA 2326717 A1 19991021; EP 1069827 A1 20010124; EP 1069827 A4 20030618
DOCDB simple family (application)
US 9907759 W 19990408; AU 3483599 A 19990408; CA 2326717 A 19990408; EP 99916535 A 19990408