EP 1070050 A1 20010124 - N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS)
Title (en)
N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS)
Title (de)
N-ARYLOXYETHYL-INDOLYL-ALKYLAMINE ZUR BEHANDLUNG VON DEPRESSIONEN (5-HT1A REZEPTOR AKTIVE AGENTIEN)
Title (fr)
N-ARYLOXYETHYL-INDOLY-ALKYLAMINES UTILISEES POUR LE TRAITEMENT DE LA DEPRESSION (PRINCIPES ACTIFS DE RECEPTEURS DU TYPE 5-HT1A)
Publication
Application
Priority
- US 9907621 W 19990407
- US 5725298 A 19980408
Abstract (en)
[origin: WO9951575A1] Compounds useful for alleviating symptoms of depression (5-HT1A receptor active agents) are provided which have formula (I), wherein: R1 is hydrogen, lower alkyl or aryl; R2 is hydrogen, lower alkyl, phenyl or substituted phenyl; X and Y are each, independently, hydrogen, lower alkyl, lower alkoxy, or halogen, or together combined with the carbon atoms to which they are attached to complete a cyclopentyl, cyclohexyl, phenyl, pyrrolyl, pyranyl, pyridinyl, dihydrofuranyl, furanyl, dioxanyl, oxazolyl or isoxazolyl group; Z is hydrogen, halogen or lower alkoxy; with the proviso that when X, Y or Z represent lower alkoxy, they are not present at the ortho position; W is hydrogen, halogen, lower alkyl, cyano or a trifluoromethyl group; and n is 2-5; or pharmaceutically acceptable salts thereof.
IPC 1-7
IPC 8 full level
A61K 31/403 (2006.01); A61K 31/404 (2006.01); A61K 31/4045 (2006.01); A61K 31/4709 (2006.01); A61P 25/24 (2006.01); C07D 209/14 (2006.01); C07D 209/16 (2006.01); C07D 209/36 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01)
CPC (source: EP)
A61P 25/24 (2017.12); C07D 209/14 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01)
Citation (search report)
See references of WO 9951575A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9951575 A1 19991014; AU 3386199 A 19991025; CA 2327359 A1 19991014; CN 1304403 A 20010718; EP 1070050 A1 20010124; JP 2002510675 A 20020409
DOCDB simple family (application)
US 9907621 W 19990407; AU 3386199 A 19990407; CA 2327359 A 19990407; CN 99807013 A 19990407; EP 99915317 A 19990407; JP 2000542296 A 19990407