Global Patent Index - EP 1070050 A1

EP 1070050 A1 2001-01-24 - N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS)

Title (en)

N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS)

Title (de)

N-ARYLOXYETHYL-INDOLYL-ALKYLAMINE ZUR BEHANDLUNG VON DEPRESSIONEN (5-HT1A REZEPTOR AKTIVE AGENTIEN)

Title (fr)

N-ARYLOXYETHYL-INDOLY-ALKYLAMINES UTILISEES POUR LE TRAITEMENT DE LA DEPRESSION (PRINCIPES ACTIFS DE RECEPTEURS DU TYPE 5-HT1A)

Publication

EP 1070050 A1 (EN)

Application

EP 99915317 A

Priority

  • US 9907621 W
  • US 5725298 A

Abstract (en)

[origin: WO9951575A1] Compounds useful for alleviating symptoms of depression (5-HT1A receptor active agents) are provided which have formula (I), wherein: R1 is hydrogen, lower alkyl or aryl; R2 is hydrogen, lower alkyl, phenyl or substituted phenyl; X and Y are each, independently, hydrogen, lower alkyl, lower alkoxy, or halogen, or together combined with the carbon atoms to which they are attached to complete a cyclopentyl, cyclohexyl, phenyl, pyrrolyl, pyranyl, pyridinyl, dihydrofuranyl, furanyl, dioxanyl, oxazolyl or isoxazolyl group; Z is hydrogen, halogen or lower alkoxy; with the proviso that when X, Y or Z represent lower alkoxy, they are not present at the ortho position; W is hydrogen, halogen, lower alkyl, cyano or a trifluoromethyl group; and n is 2-5; or pharmaceutically acceptable salts thereof.

IPC 1-7 (main, further and additional classification)

C07D 209/14; A61K 31/40

IPC 8 full level (invention and additional information)

A61K 31/403 (2006.01); A61K 31/404 (2006.01); A61K 31/4045 (2006.01); A61K 31/4709 (2006.01); A61P 25/24 (2006.01); C07D 209/14 (2006.01); C07D 209/16 (2006.01); C07D 209/36 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01)

CPC (invention and additional information)

C07D 401/12 (2013.01); C07D 209/14 (2013.01); C07D 405/12 (2013.01)

Citation (search report)

See references of WO 9951575A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9951575 A1 19991014; AU 3386199 A 19991025; CA 2327359 A1 19991014; CN 1304403 A 20010718; EP 1070050 A1 20010124; JP 2002510675 A 20020409

INPADOC legal status


2005-05-11 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20041103

2003-08-27 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030714

2002-06-19 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: WYETH

2001-03-07 [RIN1] INVENTOR (CORRECTION)

- Inventor name: MEWSHAW, RICHARD, ERIC

2001-03-07 [RIN1] INVENTOR (CORRECTION)

- Inventor name: ZHOU, DAHUI

2001-01-31 [RIN1] INVENTOR (CORRECTION)

- Inventor name: MEWSHAW, RICHARD, ERIC

2001-01-31 [RIN1] INVENTOR (CORRECTION)

- Inventor name: ZHOU, DAHUI

2001-01-24 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000929

2001-01-24 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE