Global Patent Index - EP 1070050 A1

EP 1070050 A1 20010124 - N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS)

Title (en)

N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS)

Title (de)

N-ARYLOXYETHYL-INDOLYL-ALKYLAMINE ZUR BEHANDLUNG VON DEPRESSIONEN (5-HT1A REZEPTOR AKTIVE AGENTIEN)

Title (fr)

N-ARYLOXYETHYL-INDOLY-ALKYLAMINES UTILISEES POUR LE TRAITEMENT DE LA DEPRESSION (PRINCIPES ACTIFS DE RECEPTEURS DU TYPE 5-HT1A)

Publication

EP 1070050 A1 20010124 (EN)

Application

EP 99915317 A 19990407

Priority

  • US 9907621 W 19990407
  • US 5725298 A 19980408

Abstract (en)

[origin: WO9951575A1] Compounds useful for alleviating symptoms of depression (5-HT1A receptor active agents) are provided which have formula (I), wherein: R1 is hydrogen, lower alkyl or aryl; R2 is hydrogen, lower alkyl, phenyl or substituted phenyl; X and Y are each, independently, hydrogen, lower alkyl, lower alkoxy, or halogen, or together combined with the carbon atoms to which they are attached to complete a cyclopentyl, cyclohexyl, phenyl, pyrrolyl, pyranyl, pyridinyl, dihydrofuranyl, furanyl, dioxanyl, oxazolyl or isoxazolyl group; Z is hydrogen, halogen or lower alkoxy; with the proviso that when X, Y or Z represent lower alkoxy, they are not present at the ortho position; W is hydrogen, halogen, lower alkyl, cyano or a trifluoromethyl group; and n is 2-5; or pharmaceutically acceptable salts thereof.

IPC 1-7

C07D 209/14; A61K 31/40

IPC 8 full level

A61K 31/403 (2006.01); A61K 31/404 (2006.01); A61K 31/4045 (2006.01); A61K 31/4709 (2006.01); A61P 25/24 (2006.01); C07D 209/14 (2006.01); C07D 209/16 (2006.01); C07D 209/36 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01)

CPC (source: EP)

A61P 25/24 (2018.01); C07D 209/14 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01)

Citation (search report)

See references of WO 9951575A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9951575 A1 19991014; AU 3386199 A 19991025; CA 2327359 A1 19991014; CN 1304403 A 20010718; EP 1070050 A1 20010124; JP 2002510675 A 20020409

DOCDB simple family (application)

US 9907621 W 19990407; AU 3386199 A 19990407; CA 2327359 A 19990407; CN 99807013 A 19990407; EP 99915317 A 19990407; JP 2000542296 A 19990407