EP 1070125 A2 20010124 - HUMAN NUCLEIC ACID SEQUENCES FROM NORMAL BREAST TISSUE
Title (en)
HUMAN NUCLEIC ACID SEQUENCES FROM NORMAL BREAST TISSUE
Title (de)
MENCHLICHE NUKLEINSAEUREFRAGMENTE, DEREN EXPRESSION IN BRUSTNORMALGEWEBE ERHOEHT IST
Title (fr)
SEQUENCES D'ACIDES NUCLEIQUES HUMAINS PROVENANT DE TISSUS MAMMAIRES SAINS
Publication
Application
Priority
- DE 9900909 W 19990319
- DE 19813835 A 19980320
Abstract (en)
[origin: DE19813835A1] Human nucleic acid sequences from normal breast tissue are new. A nucleic acid sequence that encodes (part of) a gene product comprises: (a) a nucleic acid sequence (I), chosen from a group of 43 sequences (given in the specification); (b) an allelic variant (II) of (I); or (c) a nucleic acid sequence (III), that is complementary to (I) or (II). Independent claims are also included for: (1) a nucleic acid sequence (76 sequences given in the specification), characterized in that it has increased expression in normal breast tissue; (2) BAC, PAC and cosmid clones, containing functional genes and their chromosomal localization, corresponding to one of 76 sequences for use as vehicles for gene transfer; (3) a nucleic acid sequence comprising part of a sequence as above which is sufficiently large to hybridize to a sequence as above; (4) an expression cassette comprising a nucleic acid fragment or a sequence as above, together with at least a control or regulatory sequence; (5) a DNA fragment, comprising a gene, that is produced as a result of using a nucleic acid sequence as above; (6) a host cell containing genetic information for expression of a heterologous nucleic acid sequence as above; (7) a process to manufacture a polypeptide or fragments, characterized in that the host cell above is cultivated; (8) an antibody against a polypeptide, which is encoded by a nucleic acid as above; (9) a polypeptide partial sequence having one of 122 sequences (given in the specification); (10) a genomic gene, its promoter, enhancer, silencer, exon and intron structure and splice variants, generated from cDNA having one of the 76 sequences; and (11) 1318, 3283 and 538 bp nucleic acid sequences characterized in that they are associated with fat metabolism and can be used to treat illnesses associated with an altered fat metabolism.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); C12Q 1/68 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07K 14/47 (2013.01)
Citation (search report)
See references of WO 9947655A2
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE
DOCDB simple family (publication)
DE 19813835 A1 19990923; EP 1070125 A2 20010124; JP 2002506639 A 20020305; WO 9947655 A2 19990923; WO 9947655 A3 20000706
DOCDB simple family (application)
DE 19813835 A 19980320; DE 9900909 W 19990319; EP 99924684 A 19990319; JP 2000536838 A 19990319