EP 1071454 A1 20010131 - CHIMERAS OF HEPATITIS C VIRUS AND BOVINE VIRAL DIARRHEA VIRUS
Title (en)
CHIMERAS OF HEPATITIS C VIRUS AND BOVINE VIRAL DIARRHEA VIRUS
Title (de)
CHIMÄREN AUS HEPATITIS C VIRUS UND BOVINE VIRALE DIARRHÖE VIRUS
Title (fr)
CHIMERES DU VIRUS DE L'HEPATITE C ET VIRUS DE LA DIARRHEE VIRALE DES BOVINS
Publication
Application
Priority
- US 9908850 W 19990423
- US 8296498 P 19980424
Abstract (en)
[origin: WO9955366A1] Disclosed is a polynucleotide comprising a chimeric viral RNA which contains: a 5' nontranslated region (5' NTR), an open reading frame (ORF) region, and a 3' nontranslated region (3' NTR) wherein at least one of said regions is chimeric. The chimeric region comprises a first nucleotide sequence from a pestivirus in operable linkage with a heterologous nucleotide sequence. The chimeric viral RNA is replication-competent. Preferably the pestivirus sequence is from a bovine viral diarrhea virus and the heterologous nucleotide sequence is from a hepatitis C virus. Also disclosed are a method for identifying compounds having antiviral activity agaisnt hepatitis C virus, a genetically-engineered chimeric RNA virus and a vaccine against bovine viral diarrhea virus.
IPC 1-7
IPC 8 full level
A61P 31/12 (2006.01); C07K 14/18 (2006.01); C12N 7/01 (2006.01)
CPC (source: EP)
A61P 31/12 (2017.12); C07K 14/005 (2013.01); A61K 2039/5256 (2013.01); C12N 2770/24222 (2013.01); C12N 2770/24322 (2013.01)
Citation (search report)
See references of WO 9955366A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9955366 A1 19991104; WO 9955366 A8 20000803; AU 3757199 A 19991116; CA 2330086 A1 19991104; EP 1071454 A1 20010131
DOCDB simple family (application)
US 9908850 W 19990423; AU 3757199 A 19990423; CA 2330086 A 19990423; EP 99919976 A 19990423