Global patent index - EP 1071454 A1

EP 1071454 A1 2001-01-31 - CHIMERAS OF HEPATITIS C VIRUS AND BOVINE VIRAL DIARRHEA VIRUS

Title (en)

CHIMERAS OF HEPATITIS C VIRUS AND BOVINE VIRAL DIARRHEA VIRUS

Title (de)

CHIMÄREN AUS HEPATITIS C VIRUS UND BOVINE VIRALE DIARRHÖE VIRUS

Title (fr)

CHIMERES DU VIRUS DE L'HEPATITE C ET VIRUS DE LA DIARRHEE VIRALE DES BOVINS

Publication

EP 1071454 A1 (EN)

Application

EP 99919976 A

Priority

  • US 9908850 W
  • US 8296498 P

Abstract (en)

[origin: WO9955366A1] Disclosed is a polynucleotide comprising a chimeric viral RNA which contains: a 5' nontranslated region (5' NTR), an open reading frame (ORF) region, and a 3' nontranslated region (3' NTR) wherein at least one of said regions is chimeric. The chimeric region comprises a first nucleotide sequence from a pestivirus in operable linkage with a heterologous nucleotide sequence. The chimeric viral RNA is replication-competent. Preferably the pestivirus sequence is from a bovine viral diarrhea virus and the heterologous nucleotide sequence is from a hepatitis C virus. Also disclosed are a method for identifying compounds having antiviral activity agaisnt hepatitis C virus, a genetically-engineered chimeric RNA virus and a vaccine against bovine viral diarrhea virus.

IPC 1-7 (main, further and additional classification)

A61K 39/29; A61K 39/295; C07H 21/02; C12N 7/01; C12Q 1/70

IPC 8 full level (invention and additional information)

A61P 31/12 (2006.01); C07K 14/18 (2006.01); C12N 7/01 (2006.01)

CPC (invention and additional information)

C07K 14/005 (2013.01); A61K 2039/5256 (2013.01); C12N 2770/24222 (2013.01); C12N 2770/24322 (2013.01)

Citation (search report)

See references of WO 9955366A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9955366 A1 19991104; WO 9955366 A8 20000803; AU 3757199 A 19991116; CA 2330086 A1 19991104; EP 1071454 A1 20010131

INPADOC legal status

2002-05-22 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20010503

2001-01-31 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20001116

2001-01-31 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE