EP 1071459 A1 20010131 - METHODS TO PROVOKE ANTI-CANCER IMMUNE RESPONSES
Title (en)
METHODS TO PROVOKE ANTI-CANCER IMMUNE RESPONSES
Title (de)
VERFAHREN ZUR ERREGUNG VON IMMUNREAKTIONEN GEGEN KREBS
Title (fr)
METHODES POUR PROVOQUER DES REPONSES IMMUNITAIRES ANTICANCEREUSES
Publication
Application
Priority
- US 9906048 W 19990319
- US 7893198 P 19980320
Abstract (en)
[origin: WO9947169A1] The present invention provides methods for inducing an antigen-specific immune response. In one aspect, an effective amount of an antigenic peptide binding protein (APBP) and a cytotoxic agent are administered to the subject. In another aspect, an effective amount of a first polynucleotide encoding an antigenic peptide binding protein and a second polynucleotide encoding a cytotoxic agent are administered to the subject. In another aspect, the methods described herein also include administering an effective amount of an antigen presenting cell (APC) recruitment factor, a cytokine or a co-stimulatory molecule. In yet another embodiment, the cytotoxic agent and the antigen presenting cell recruitment factor are encoded by one polynucleotide. In yet another aspect, the invention provides a method of adoptive immunotherapy by administering to a subject a population of educated, antigen-specific immune effector cells, with or without an effective amount of a cytokine and/or a co-stimulator molecule.
IPC 1-7
A61K 39/395; A61K 45/00; A61K 45/05; A01N 37/18; A01N 43/04; A01N 63/00; C12N 5/02; C12N 5/06; C12N 5/08; C07K 1/00; C07K 16/46; C07H 21/04
IPC 8 full level
C12N 15/09 (2006.01); A01N 37/18 (2006.01); A01N 43/04 (2006.01); A61K 35/76 (2006.01); A61K 38/17 (2006.01); A61K 38/45 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); A61P 37/04 (2006.01); A61P 43/00 (2006.01); C07H 21/04 (2006.01); C07K 16/46 (2006.01); C12N 5/02 (2006.01)
CPC (source: EP US)
A61K 38/1709 (2013.01 - EP); A61K 38/45 (2013.01 - EP); A61K 39/001176 (2018.08 - EP US); A61P 35/00 (2018.01 - EP); A61P 37/04 (2018.01 - EP); A61P 43/00 (2018.01 - EP); A61K 2039/6043 (2013.01 - EP); A61K 2039/605 (2013.01 - EP)
C-Set (source: EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9947169 A1 19990923; AU 3103699 A 19991011; AU 755706 B2 20021219; CA 2322969 A1 19990923; EP 1071459 A1 20010131; EP 1071459 A4 20020717; JP 2002506832 A 20020305
DOCDB simple family (application)
US 9906048 W 19990319; AU 3103699 A 19990319; CA 2322969 A 19990319; EP 99912724 A 19990319; JP 2000536408 A 19990319