Global patent index - EP 1071459 A1

EP 1071459 A1 2001-01-31 - METHODS TO PROVOKE ANTI-CANCER IMMUNE RESPONSES

Title (en)

METHODS TO PROVOKE ANTI-CANCER IMMUNE RESPONSES

Title (de)

VERFAHREN ZUR ERREGUNG VON IMMUNREAKTIONEN GEGEN KREBS

Title (fr)

METHODES POUR PROVOQUER DES REPONSES IMMUNITAIRES ANTICANCEREUSES

Publication

EP 1071459 A1 (EN)

Application

EP 99912724 A

Priority

  • US 9906048 W
  • US 7893198 P

Abstract (en)

[origin: WO9947169A1] The present invention provides methods for inducing an antigen-specific immune response. In one aspect, an effective amount of an antigenic peptide binding protein (APBP) and a cytotoxic agent are administered to the subject. In another aspect, an effective amount of a first polynucleotide encoding an antigenic peptide binding protein and a second polynucleotide encoding a cytotoxic agent are administered to the subject. In another aspect, the methods described herein also include administering an effective amount of an antigen presenting cell (APC) recruitment factor, a cytokine or a co-stimulatory molecule. In yet another embodiment, the cytotoxic agent and the antigen presenting cell recruitment factor are encoded by one polynucleotide. In yet another aspect, the invention provides a method of adoptive immunotherapy by administering to a subject a population of educated, antigen-specific immune effector cells, with or without an effective amount of a cytokine and/or a co-stimulator molecule.

IPC 1-7 (main, further and additional classification)

A61K 39/395; A01N 37/18; A01N 43/04; A01N 63/00; A61K 45/00; C07H 21/04; C07K 1/00; C07K 16/46; C12N 5/02; C12N 5/06; C12N 5/08; A61K 45/05

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A01N 37/18 (2006.01); A01N 43/04 (2006.01); A61K 35/76 (2006.01); A61K 38/17 (2006.01); A61K 38/45 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); A61P 37/04 (2006.01); A61P 43/00 (2006.01); C07H 21/04 (2006.01); C07K 16/46 (2006.01); C12N 5/02 (2006.01)

CPC (invention and additional information)

A61K 39/0011 (2013.01); A61K 38/1709 (2013.01); A61K 38/45 (2013.01); A61K 2039/6043 (2013.01); A61K 2039/605 (2013.01)

Combination set (CPC)

  1. A61K 38/1709 + A61K 2300/00
  2. A61K 38/45 + A61K 2300/00

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9947169 A1 19990923; AU 3103699 A 19991011; AU 755706 B2 20021219; CA 2322969 A1 19990923; EP 1071459 A1 20010131; EP 1071459 A4 20020717; JP 2002506832 A 20020305

INPADOC legal status

2003-02-26 [18W] WITHDRAWN

- Ref Legal Event Code: 18W

- Effective date: 20021219

2002-10-16 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20020902

2002-07-17 [A4] SUPPLEMENTARY SEARCH REPORT

- Ref Legal Event Code: A4

- Effective date: 20020604

2002-07-17 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-01-31 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000920

2001-01-31 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE