Global Patent Index - EP 1071472 A1

EP 1071472 A1 2001-01-31 - PEPTIDES FOR EFFICIENT GENE TRANSFER

Title (en)

PEPTIDES FOR EFFICIENT GENE TRANSFER

Title (de)

PEPTIDE FÜR EINEN EFFIZIENTEN GENTRANSFER

Title (fr)

PEPTIDES PERMETTANT UN TRANSFERT GENIQUE EFFICACE

Publication

EP 1071472 A1 (EN)

Application

EP 99919987 A

Priority

  • US 9908884 W
  • US 6589198 A

Abstract (en)

[origin: WO9953961A1] The present invention relates to nucleic acid condensates comprising a nucleic acid bound to a polycationic peptide, and in particular a CWK (cysteine, tryptophan, lysine) polycationic peptide, and to methods of making and using such condensates. The invention further relates to a novel pharmaceutical compositions comprising condensed DNA incorporated into matrices (gene-activated matrices) that may be utilized for delivery of nucleic acids into targeted cells. The invention further relates to methods for producing gene-activated matrices involving the addition of polycationic peptides, and in particular a CWK polycationic peptide, to negatively charged DNA prior to incorporation into a matrix. The invention further relates to the linkage of the polycationic peptides to ligand molecules, thus permitting targeting of the DNA to specific targeted cell types. The present invention provides pharmaceutical formulations and methods that are applicable to wound healing and a wide variety of genetic or acquired diseases.

IPC 1-7 (main, further and additional classification)

A61K 48/00; C12N 15/00; C12N 15/11; C12N 15/63; C12N 15/85; C12N 15/86

IPC 8 full level (invention and additional information)

A61K 48/00 (2006.01); A61P 17/02 (2006.01); C07K 14/00 (2006.01); C12N 15/87 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

A61K 48/00 (2013.01); C07K 14/001 (2013.01); C12N 15/87 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9953961 A1 19991028; WO 9953961 A9 20000908; AU 3758199 A 19991108; EP 1071472 A1 20010131; EP 1071472 A4 20020417

INPADOC legal status


2004-12-22 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20040617

2004-03-24 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20040206

2002-04-17 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20020305

2002-04-17 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-01-31 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20001030

2001-01-31 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE