EP 1071475 A2 20010131 - CD4 RADIO-IMMUNOLOGICAL PHARMACEUTICALS FOR THE TREATMENT OF HIV INFECTIONS
Title (en)
CD4 RADIO-IMMUNOLOGICAL PHARMACEUTICALS FOR THE TREATMENT OF HIV INFECTIONS
Title (de)
CD4-RADIOIMMUNPHARMAKA ZUR BEHANDLUNG DER HIV-INFEKTION
Title (fr)
SUBSTANCES PHARMACEUTIQUES RADIO-IMMUNOLOGIQUES A BASE DE CD4 DESTINEES AU TRAITEMENT DE L'INFECTION PAR LE VIH
Publication
Application
Priority
- DE 9901177 W 19990415
- DE 19826307 A 19980415
Abstract (en)
[origin: WO9954954A2] The disadvantages of standard HIV therapies are as follows: currently used medicaments must be taken in large quantities each day during an entire lifetime according to a strict timetable and have a large number of side effects. Traditional medicaments only manage to restrict virus replication. Host cells infected with HIV are not eliminated. For this reason it was not previously possible to cure HIV infections. The current application describes, as an additional application to PCT patent application (PCT/DE99/00598) dated 8.3.99, radio-immunological pharmaceuticals consisting of a CD4 molecule or a fragment derived therefrom and a radionuclide for in-vivo elimination of HIV replicating cells in HIV-1 and HIV-2 infected patients. The combination of HIV affine CD4 receptor molecules or fragments with radionuclides for therapeutic purposes, especially for use in radioimmunological anti-HIV therapy is totally novel. The radioimmunological pharmaceuticals are to be administered intravenously to HIV-1 or HIV-2 infected patients once or in several cycles in order to cause sustained damage to HIV replicating cells in a targeted manner so that the latter can be fully eliminated.
IPC 1-7
IPC 8 full level
A61K 51/00 (2006.01); A61K 51/08 (2006.01); A61P 31/18 (2006.01); C07K 14/705 (2006.01)
CPC (source: EP)
A61K 51/08 (2013.01); A61P 31/18 (2017.12)
Citation (search report)
See references of WO 9954954A2
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9954954 A2 19991028; WO 9954954 A3 20000120; AU 4497199 A 19991108; DE 19980721 D2 20010329; EP 1071475 A2 20010131; JP 2002512261 A 20020423
DOCDB simple family (application)
DE 9901177 W 19990415; AU 4497199 A 19990415; DE 19980721 T 19990415; EP 99927685 A 19990415; JP 2000545211 A 19990415