EP 1071697 A1 20010131 - REGULATED TARGET EXPRESSION FOR SCREENING
Title (en)
REGULATED TARGET EXPRESSION FOR SCREENING
Title (de)
REGULIERTE ZIELEXPRESSION ZUR ERKENNUNG
Title (fr)
EXPRESSION REGULEE DE CIBLES A DES FINS DE CRIBLAGE
Publication
Application
Priority
- US 9908164 W 19990414
- US 9856398 P 19980414
- US 8295298 P 19980424
- US 10043098 P 19980710
- US 10544198 P 19981023
- US 10544798 P 19981023
- US 11775899 P 19990129
- US 11795599 P 19990129
Abstract (en)
[origin: WO9952926A1] Methods and compositions for screening compounds for potential therapeutic activity and for identifying drug targets are provided. The methods rely on controlled expression (either underexpression or overexpression) of an essential cellular gene, which can be achieved, in one embodiment, by fusion of a heterologous regulatory element to the gene. The method is capable of identifying a drug target in the absence of any knowledge of target function.
IPC 1-7
C07H 21/04; C12N 1/12; C12N 1/14; C12N 1/20; C12N 15/63; C12P 21/02; C12Q 1/00; C12Q 1/02; C12Q 1/04
IPC 8 full level
A61K 45/00 (2006.01); A61P 43/00 (2006.01); C07K 14/245 (2006.01); C07K 14/31 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/06 (2006.01); C12N 9/10 (2006.01); C12N 9/24 (2006.01); C12N 9/78 (2006.01); C12N 9/90 (2006.01); C12N 15/09 (2006.01); C12N 15/63 (2006.01); C12P 21/02 (2006.01); C12Q 1/02 (2006.01); C12Q 1/04 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)
CPC (source: EP)
A61P 43/00 (2017.12); C07K 14/245 (2013.01); C07K 14/31 (2013.01); C12N 9/003 (2013.01); C12N 9/1085 (2013.01); C12N 9/2465 (2013.01); C12N 9/78 (2013.01); C12N 9/90 (2013.01); C12N 15/63 (2013.01); C12Q 1/6897 (2013.01); C12Y 302/01022 (2013.01); C07K 2319/00 (2013.01)
Citation (search report)
See references of WO 9952926A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9952926 A1 19991021; CA 2325602 A1 19991021; EP 1071697 A1 20010131; JP 2002511239 A 20020416
DOCDB simple family (application)
US 9908164 W 19990414; CA 2325602 A 19990414; EP 99917494 A 19990414; JP 2000543482 A 19990414