Global Patent Index - EP 1071697 A1

EP 1071697 A1 2001-01-31 - REGULATED TARGET EXPRESSION FOR SCREENING

Title (en)

REGULATED TARGET EXPRESSION FOR SCREENING

Title (de)

REGULIERTE ZIELEXPRESSION ZUR ERKENNUNG

Title (fr)

EXPRESSION REGULEE DE CIBLES A DES FINS DE CRIBLAGE

Publication

EP 1071697 A1 (EN)

Application

EP 99917494 A

Priority

  • US 9908164 W
  • US 9856398 P
  • US 8295298 P
  • US 10043098 P
  • US 10544198 P
  • US 10544798 P
  • US 11775899 P
  • US 11795599 P

Abstract (en)

[origin: WO9952926A1] Methods and compositions for screening compounds for potential therapeutic activity and for identifying drug targets are provided. The methods rely on controlled expression (either underexpression or overexpression) of an essential cellular gene, which can be achieved, in one embodiment, by fusion of a heterologous regulatory element to the gene. The method is capable of identifying a drug target in the absence of any knowledge of target function.

IPC 1-7 (main, further and additional classification)

C07H 21/04; C12N 1/12; C12N 1/14; C12N 1/20; C12N 15/63; C12P 21/02; C12Q 1/00; C12Q 1/02; C12Q 1/04

IPC 8 full level (invention and additional information)

G01N 33/50 (2006.01); A61K 45/00 (2006.01); A61P 43/00 (2006.01); C07K 14/245 (2006.01); C07K 14/31 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/06 (2006.01); C12N 9/10 (2006.01); C12N 9/24 (2006.01); C12N 9/78 (2006.01); C12N 9/90 (2006.01); C12N 15/09 (2006.01); C12N 15/63 (2006.01); C12P 21/02 (2006.01); C12Q 1/02 (2006.01); C12Q 1/04 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01)

CPC (invention and additional information)

C12N 9/003 (2013.01); C07K 14/245 (2013.01); C07K 14/31 (2013.01); C12N 9/1085 (2013.01); C12N 9/2465 (2013.01); C12N 9/78 (2013.01); C12N 9/90 (2013.01); C12N 15/63 (2013.01); C12Q 1/6897 (2013.01); C12Y 302/01022 (2013.01); C07K 2319/00 (2013.01)

Citation (search report)

See references of WO 9952926A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9952926 A1 19991021; CA 2325602 A1 19991021; EP 1071697 A1 20010131; JP 2002511239 A 20020416

INPADOC legal status


2003-05-28 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20021101

2001-01-31 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20001109

2001-01-31 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE