EP 1071705 A2 20010131 - PEPTIDES CAUSING FORMATION OF COMPACT STRUCTURES
Title (en)
PEPTIDES CAUSING FORMATION OF COMPACT STRUCTURES
Title (de)
PEPTIDE, DIE ZUR AUSBILDUNG KOMPAKTER STRUKTUREN FÜHREN
Title (fr)
PEPTIDES PROVOQUANT LA FORMATION DE STRUCTURES COMPACTES
Publication
Application
Priority
- US 9907374 W 19990402
- US 8044498 P 19980402
Abstract (en)
[origin: WO9951625A2] The present invention is directed to compositions and methods comprising peptides which have a high affinity for each other and, when linked to a protein, are used to help fold the protein into a compact structure. By virtue of its stability and constraints, this scaffold can prolong the activity of any embedded protein sequences in the presence of cellular and other proteases. The compact structure can have other functional sequences embedded, and is preferable to linear and less constrained peptides for library screening, for creating structurally-biased peptide libraries and for targeting to specific intracellular and extracellular compartments. Compositions of the present invention can be displayed on the surface of viruses, archaebacteria, prokaryotic and eukaryotic cells for library screening, drug screening and display. Methods of the present invention are useful for screening in vivo for intracellular effector proteins modulating signaling pathways and to identify interacting proteins in vitro. Thus, the present invention is useful as a scaffold for gene therapy, for the isolation of new therapeutic drug leads and for potential use as a therapeutic in physiological fluids.
IPC 1-7
IPC 8 full level
C07K 1/04 (2006.01); C07K 7/06 (2006.01); C07K 14/00 (2006.01); C07K 14/47 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01)
CPC (source: EP)
C07K 1/047 (2013.01); C07K 7/06 (2013.01); C07K 14/47 (2013.01)
Citation (search report)
See references of WO 9951625A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9951625 A2 19991014; WO 9951625 A3 20000406; WO 9951625 A9 20010705; AU 3469399 A 19991025; AU 752168 B2 20020905; CA 2324284 A1 19991014; CN 1302305 A 20010704; EP 1071705 A2 20010131; JP 2002510479 A 20020409; NZ 507063 A 20031128
DOCDB simple family (application)
US 9907374 W 19990402; AU 3469399 A 19990402; CA 2324284 A 19990402; CN 99806463 A 19990402; EP 99916352 A 19990402; JP 2000542346 A 19990402; NZ 50706399 A 19990402