EP 1071718 A1 20010131 - MATRIX BINDING FACTOR
Title (en)
MATRIX BINDING FACTOR
Title (de)
EIN AN EINE MATRIX BINDENDER FAKTOR
Title (fr)
FACTEUR DE LIAISON MATRICIELLE
Publication
Application
Priority
- AU 9900292 W 19990419
- AU PP298498 A 19980417
Abstract (en)
[origin: WO9954359A1] The present invention relates to the design, manufacture and use of novel polypeptide bioactive factors. More particularly, the invention relates to the targeting of polypeptide bioactive factors to biological or chemical substrates via engineered amino acid motifs, while maintaining or extending the biological activities attributed to that polypeptide bioactive factor. The invention provides a recombinant polypeptide bioactive factor, referred to as a matrix binding factor (MBF), comprising a polypeptide bioactive factor in which the naturally-occurring amino acid sequence of the factor has been modified to introduce one or more amino acid substitutions, deletions and/or additions which increase the affinity of the polypeptide bioactive factor for a negatively-charged surface. Preferably the polypeptide bioactive factor is a growth factor which stimulates proliferation, differentiation, migration or cellular activity, and most preferably is a member of the insulin-like growth factor (IGF) family of growth factors. The invention also provides nucleic acid molecules encoding polypeptide bioactive factors of the invention, methods for production of the factors, and compositions and methods for use of the factors in treatment of a variety of pathological conditions, for use in tissue culture and for the preparation and use of surgical implants or prostheses.
IPC 1-7
C07K 19/00; C07K 14/65; C07H 21/04; C12N 15/62; C12N 15/12; C12N 15/19; C12N 15/16; C12N 9/20; C12N 9/74; A61K 38/18; A61L 27/00
IPC 8 full level
C12N 15/09 (2006.01); A61K 8/64 (2006.01); A61K 8/96 (2006.01); A61K 38/22 (2006.01); A61L 27/00 (2006.01); A61L 27/22 (2006.01); A61P 1/02 (2006.01); A61P 1/04 (2006.01); A61P 17/02 (2006.01); A61P 43/00 (2006.01); A61Q 11/00 (2006.01); C07K 14/47 (2006.01); C07K 14/475 (2006.01); C07K 14/50 (2006.01); C07K 14/65 (2006.01); C07K 19/00 (2006.01); C12M 1/00 (2006.01); C12N 5/00 (2006.01); C12P 21/02 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61L 27/227 (2013.01); A61P 1/02 (2017.12); A61P 1/04 (2017.12); A61P 17/02 (2017.12); A61P 43/00 (2017.12); C07K 14/65 (2013.01); C12N 5/0068 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C12N 2533/50 (2013.01)
Designated contracting state (EPC)
DE FR GB IT
DOCDB simple family (publication)
WO 9954359 A1 19991028; AU PP298498 A0 19980507; CA 2328463 A1 19991028; EP 1071718 A1 20010131; EP 1071718 A4 20030702; JP 2002512018 A 20020423
DOCDB simple family (application)
AU 9900292 W 19990419; AU PP298498 A 19980417; CA 2328463 A 19990419; EP 99915364 A 19990419; JP 2000544697 A 19990419