EP 1071765 A1 20010131 - ALK-1 RESPONDS TO TGF-BETA AND SIGNALS THROUGH SMAD-1 AND SMAD-5
Title (en)
ALK-1 RESPONDS TO TGF-BETA AND SIGNALS THROUGH SMAD-1 AND SMAD-5
Title (de)
ALK-1 REAGIERT AUF TGF-BETA UND GIBT DIE SIGNALE WEITER MITTELS SMAD-1 UND SMAD-5
Title (fr)
REACTIONS DE ALK-1 AU TGF-BETA ET DES SIGNAUX TRAVERSANT SMAD-1 ET SMAD-5
Publication
Application
Priority
- US 9905735 W 19990312
- US 3917798 A 19980313
Abstract (en)
[origin: WO9946386A1] The invention relates to the molecule referred to as ALK-1, and its role as a type I receptor for members of the TGF- beta family. The molecule has a role in the phosphorylation of Smad-5 and Smad-1, which also act as activators of certain genes. Aspects of the invention relate to this interaction.
IPC 1-7
C12N 15/12; C07K 14/71; C07K 16/28; A61K 38/18; A61K 38/17; A61K 39/395; G01N 33/50; C12Q 1/68
IPC 8 full level
C07K 14/71 (2006.01); C07K 16/28 (2006.01); C12N 15/12 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 14/71 (2013.01); C07K 16/2863 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9946386 A1 19990916; WO 9946386 B1 19991021; AU 3092899 A 19990927; EP 1071765 A1 20010131; EP 1071765 A4 20030115; EP 2078752 A2 20090715; EP 2078752 A3 20090923
DOCDB simple family (application)
US 9905735 W 19990312; AU 3092899 A 19990312; EP 09156929 A 19990312; EP 99912583 A 19990312