EP 1071773 A1 20010131 - SH2 DOMAIN-CONTAINING PEPTIDES
Title (en)
SH2 DOMAIN-CONTAINING PEPTIDES
Title (de)
PEPTIDEN DIE EIN SH2-DOMAIN ENTHALTEN
Title (fr)
PEPTIDES CONTENANT LE DOMAINE SH2
Publication
Application
Priority
- US 9908847 W 19990423
- US 8276798 P 19980423
- US 11329698 P 19981222
Abstract (en)
[origin: WO9954467A1] The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, antagonists and agonists vectors and host cells expressing, and immunoadhesions and antibodies to PRO201, PRO308 or PRO309 polypeptides. The invention further relates to compositions and method for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based in part on the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain tumors (e.g. cancer) and may act as predictors of the prognosis of tumor treatment.
IPC 1-7
C12N 15/12; C07K 14/47; G01N 33/53; C12Q 1/68; C12N 15/62; C12N 15/11; C07K 16/18
IPC 8 full level
G01N 33/53 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C07K 16/42 (2006.01); C07K 19/00 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
C07K 14/47 (2013.01); C07K 2319/02 (2013.01)
Citation (search report)
See references of WO 9954467A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated extension state (EPC)
AL LT LV MK RO SI
DOCDB simple family (publication)
WO 9954467 A1 19991028; WO 9954467 A9 19991216; AU 3757099 A 19991108; AU 741133 B2 20011122; CA 2324297 A1 19991028; EP 1071773 A1 20010131; JP 2002512032 A 20020423; JP 3659405 B2 20050615
DOCDB simple family (application)
US 9908847 W 19990423; AU 3757099 A 19990423; CA 2324297 A 19990423; EP 99919975 A 19990423; JP 2000544799 A 19990423