Global Patent Index - EP 1071796 A1

EP 1071796 A1 2001-01-31 - REGULABLE GENE EXPRESSION IN GRAM-POSITIVE BACTERIA

Title (en)

REGULABLE GENE EXPRESSION IN GRAM-POSITIVE BACTERIA

Title (de)

REGULIEBARE GENEXPRESSION IN GRAM-POSITIVEN BAKTERIEN

Title (fr)

EXPRESSION GENIQUE REGULABLE DANS DES BACTERIES GRAM POSITIF

Publication

EP 1071796 A1 (EN)

Application

EP 99919834 A

Priority

  • US 9908155 W
  • US 8175398 P
  • US 8584498 P
  • US 8982898 P
  • US 9469898 P
  • US 10021198 P
  • US 10171898 P
  • US 10775198 P
  • US 22768799 A
  • US 12294999 P

Abstract (en)

[origin: CA2325662A1] A system has been constructed which is suitable for tetracycline-inducible gene expression in Gram-positive bacteria such as Staphylococcus aureus and Bacillus subtilis. The replicon/host gene expression system is tightly regulated, can be used in complex as well as minimal media, and can produce a high level of gene expression upon induction, with a variety of gene products. The gene expression system is suitable for production of products toxic to the host cells, and can be used, for example, for the analysis of gene expression and gene products in Gram-positive bacteria, and in a test of the effect of a peptide or polypeptide inhibitor of an S. aureus enzyme on the growth of S. aureus cells in culture or during infection of an animal.

IPC 1-7 (main, further and additional classification)

C12N 15/63; A01K 67/027; C12N 1/21; C12N 15/74; C12Q 1/68

IPC 8 full level (invention and additional information)

A01K 67/027 (2006.01); C12N 1/21 (2006.01); C12N 15/63 (2006.01); C12N 15/74 (2006.01); C12Q 1/68 (2006.01)

IPC 8 main group level (invention and additional information)

C12N (2006.01)

Citation (search report)

See references of WO 9953079A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

AU 3746599 A 19991101; CA 2325662 A1 19991021; EP 1071796 A1 20010131; NO 20005157 A 20001211; NO 20005157 D0 20001013

INPADOC legal status


2007-11-23 [REG HK WD] APPLICATIONS WITHDRAWN, DEEMED TO BE WITHDRAWN, OR REFUSED AFTER PUBLICATION IN HONG KONG

- Document: HK 1033959

2006-05-10 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20051101

2003-12-10 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20031022

2001-01-31 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20001019

2001-01-31 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE