EP 1071796 A1 20010131 - REGULABLE GENE EXPRESSION IN GRAM-POSITIVE BACTERIA
Title (en)
REGULABLE GENE EXPRESSION IN GRAM-POSITIVE BACTERIA
Title (de)
REGULIEBARE GENEXPRESSION IN GRAM-POSITIVEN BAKTERIEN
Title (fr)
EXPRESSION GENIQUE REGULABLE DANS DES BACTERIES GRAM POSITIF
Publication
Application
Priority
- US 9908155 W 19990414
- US 8175398 P 19980414
- US 8584498 P 19980518
- US 8982898 P 19980619
- US 9469898 P 19980730
- US 10021198 P 19980914
- US 10171898 P 19980924
- US 10775198 P 19981110
- US 22768799 A 19990108
- US 12294999 P 19990305
Abstract (en)
[origin: CA2325662A1] A system has been constructed which is suitable for tetracycline-inducible gene expression in Gram-positive bacteria such as Staphylococcus aureus and Bacillus subtilis. The replicon/host gene expression system is tightly regulated, can be used in complex as well as minimal media, and can produce a high level of gene expression upon induction, with a variety of gene products. The gene expression system is suitable for production of products toxic to the host cells, and can be used, for example, for the analysis of gene expression and gene products in Gram-positive bacteria, and in a test of the effect of a peptide or polypeptide inhibitor of an S. aureus enzyme on the growth of S. aureus cells in culture or during infection of an animal.
IPC 1-7
IPC 8 full level
A01K 67/027 (2006.01); C12N 1/21 (2006.01); C12N 15/63 (2006.01); C12N 15/74 (2006.01); C12Q 1/68 (2006.01)
IPC 8 main group level
C12N (2006.01)
Citation (search report)
See references of WO 9953079A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
AU 3746599 A 19991101; CA 2325662 A1 19991021; EP 1071796 A1 20010131; NO 20005157 D0 20001013; NO 20005157 L 20001211
DOCDB simple family (application)
AU 3746599 A 19990414; CA 2325662 A 19990414; EP 99919834 A 19990414; NO 20005157 A 20001013