EP 1073332 A4 20050615 - R-RABEPRAZOLE COMPOSITIONS AND METHODS
Title (en)
R-RABEPRAZOLE COMPOSITIONS AND METHODS
Title (de)
R-RABEPRAZOL ENTHALTENDE ZUSAMMENSETZUNGEN UND VERFAHREN
Title (fr)
COMPOSITIONS A BASE DE R-RABEPRAZOLE ET PROCEDES
Publication
Application
Priority
- US 9909205 W 19990428
- US 8372598 P 19980430
Abstract (en)
[origin: WO9955157A1] Methods and compositions are disclosed utilizing optically pure (+) rabeprazole for the treatment of ulcers in humans while substantially reducing the concomitant liability of adverse effects associated with the racemic mixture of rabeprazole. The optically pure (+) isomer is also useful for the treatment of gastroesophageal reflux. (+) Rabeprazole is an inhibitor of H<+> release and is therefore useful in the treatment of other conditions related to gastric hypersecretion such as Zollinger-Ellison Syndrome.
IPC 1-7
IPC 8 full level
C07D 401/12 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01); A61K 31/44 (2006.01); A61K 31/4427 (2006.01); A61K 31/4439 (2006.01); A61P 1/04 (2006.01); A61P 17/06 (2006.01)
CPC (source: EP)
A61K 31/44 (2013.01); A61P 1/04 (2017.12); A61P 17/06 (2017.12)
Citation (search report)
- [XD] US 5045552 A 19910903 - SOUDA SHIGERU [JP], et al
- [E] DE 19801811 A1 19990722 - STADA ARZNEIMITTEL AG [DE]
- [XY] DATABASE WPI Week 199601, Derwent World Patents Index; AN 1996-003307, XP002312212 & DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002312211, retrieved from STN accession no. 2002:772730 Database accession no. 137:247700
- [Y] NOCHI S ET AL: "PREPARATION AND ABSOLUTE CONFIGURATIONS OF OPTICAL ISOMERS OF SODIUM 2-[[4-(3-METHOXYPROPOXY)-3-METHYLPYRIDIN-2YLÜMETHYLSULFINYLÜ-1H-BENZI MIDAZOLE (E3810)", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN. TOKYO, JP, vol. 44, no. 10, October 1996 (1996-10-01), pages 1853 - 1857, XP009014313, ISSN: 0009-2363
- [Y] TAKAKUWA S ET AL: "Enantioselective high-performance liquid chromatographic assay for determination of the enantiomers of a new anti-ulcer agent, E3810, in Beagle dog plasma and rat plasma", JOURNAL OF CHROMATOGRAPHY B : BIOMEDICAL APPLICATIONS, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 673, no. 1, 3 November 1995 (1995-11-03), pages 113 - 122, XP004043535, ISSN: 0378-4347
- [PY] MIGNON M ET AL: "Rabeprazole therapy effective in Zollinger-Ellison syndrome and idiopathic gastric acid hypersecretion", GUT, vol. 44, no. SUPPL. 1, April 1999 (1999-04-01), & BRITISH SOCIETY OF GASTROENTEROLOGY ANNUAL MEETING; GLASGOW, SCOTLAND, UK; MARCH 23-25, 1999, pages A125, XP008040883, ISSN: 0017-5749
- [PY] RICHARDSON P ET AL: "PROTON PUMP INHIBITORS. PHARMACOLOGY AND RATIONALE FOR USE IN GASTROINSTESTINAL DISORDERS", DRUGS, ADIS INTERNATIONAL LTD, AT, vol. 56, no. 3, 1998, pages 307 - 335, XP000960763, ISSN: 0012-6667
- [A] PRAKASH A ET AL: "Rabeprazole.", DRUGS. FEB 1998, vol. 55, no. 2, February 1998 (1998-02-01), pages 261 - 267 ; dis, XP008040880, ISSN: 0012-6667
- See references of WO 9955157A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9955157 A1 19991104; AU 3870599 A 19991116; CA 2330139 A1 19991104; EP 1073332 A1 20010207; EP 1073332 A4 20050615; JP 2002512262 A 20020423
DOCDB simple family (application)
US 9909205 W 19990428; AU 3870599 A 19990428; CA 2330139 A 19990428; EP 99921512 A 19990428; JP 2000545374 A 19990428