Global Patent Index - EP 1073420 A4

EP 1073420 A4 20040908 - SPECIALLY DEVISED NEURONAL IMPLANTS FOR RECONSTRUCTION OF DAMAGED CENTRAL NERVOUS SYSTEM

Title (en)

SPECIALLY DEVISED NEURONAL IMPLANTS FOR RECONSTRUCTION OF DAMAGED CENTRAL NERVOUS SYSTEM

Title (de)

SPEZIELL AUSGEDACHTES NEURONALIMPLANT ZUM WIEDERAUFBAU VOM BESCHÄDIGTEN ZENTRALNERVENSYSTEM

Title (fr)

IMPLANTS NEURONAUX SPECIAUX, POUR LA RECONSTRUCTION DU SYSTEME NERVEUX CENTRAL ENDOMMAGE

Publication

EP 1073420 A4 20040908 (EN)

Application

EP 99919517 A 19990514

Priority

  • IL 9900257 W 19990514
  • US 8550298 P 19980514

Abstract (en)

[origin: WO9958042A2] Specially devised neuronal implants for reconstruction of damaged central nervous system are prepared by culturing embryonal or neonatal tissue explants in a suspension culture with biodegradable microcarriers allowing formation of cellular-microcarrier aggregates. The cellular-microcarrier aggregates are transferred to plastic dishes coated with a matrix gel composed of hyaluronic acid and laminin, and the cellular-microcarrier aggregates are cultured in a suitable culture medium, forming a composite implant suitable for transplantation.

IPC 1-7

A61K 9/16; A61K 31/715; C12M 3/02

IPC 8 full level

A61K 35/30 (2006.01); C12N 5/06 (2006.01); C12N 5/0793 (2010.01); C12N 5/08 (2006.01)

CPC (source: EP)

A61K 35/30 (2013.01); C12N 5/0619 (2013.01); C12N 2506/08 (2013.01)

Citation (search report)

  • [X] WO 9314790 A1 19930805 - UNIV NEW YORK [US]
  • [X] WO 9219195 A1 19921112 - UNIV BROWN RES FOUND [US]
  • [X] SHAHAR A ET AL: "Tissue culture models in the study of neuroregeneration and neurodegenerative processes", JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, vol. 54, no. SUPPL., 1995, Symposium on Brain Research and Society;Barcelona, Spain; September 21-24, 1995, pages 20S - 21S, XP009032967, ISSN: 0022-3069
  • [X] ROCHKIND S ET AL.: "A combined procedure of cultured embryonic cells implantation and low power laser treatment to cure paraplegic rats following complete spinal cord transection", CLINICAL NEUROLOGY AND NEUROSURGERY, vol. 99 suppl. 1, July 1997 (1997-07-01), pages S143, XP002286486
  • [X] ROCHKIND S ET AL: "A combined procedure utilizing cultured embryonal cell implantation and low power laser treatment to cure paraplegic rats following complete spinal cord transection", PROCEEDINGS OF THE 11TH INTERNATIONAL CONGRESS OF NEUROLOGICAL SURGERY, AMSTERDAM, THE NETHERLANDS, 6 July 1997 (1997-07-06) - 11 July 1997 (1997-07-11), pages 1903 - 1908, XP009032880
  • [T] ROCHKIND S ET AL: "Transplantation of embryonal spinal cord nerve cells cultured on biodegradable microcarriers followed by low power laser irradiation for the treatment of traumatic paraplegia in rats", NEUROLOGICAL RESEARCH, vol. 24, no. 4, June 2002 (2002-06-01), pages 355 - 360, XP002286758, ISSN: 0161-6412
  • See references of WO 9958042A2

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE

DOCDB simple family (publication)

WO 9958042 A2 19991118; WO 9958042 A3 20000406; AU 3728099 A 19991129; EP 1073420 A2 20010207; EP 1073420 A4 20040908

DOCDB simple family (application)

IL 9900257 W 19990514; AU 3728099 A 19990514; EP 99919517 A 19990514