Global Patent Index - EP 1073423 A1

EP 1073423 A1 2001-02-07 - COATED DONUT-SHAPED TABLETS WITH LONG-TERM PARABOLIC AND ZERO-ORDER RELEASE KINETICS

Title (en)

COATED DONUT-SHAPED TABLETS WITH LONG-TERM PARABOLIC AND ZERO-ORDER RELEASE KINETICS

Title (de)

DONUTFÖRMIGE BESCHICHTETE TABLETTEN MIT EINER LANGANHALTENDEN PARABOLISCHEN UND NULLTER ORDNUNG KINETIK

Title (fr)

COMPRIMES ARRONDIS ENROBES POUR UNE LIBERATION SOUTENUE A UNE VITESSE CONSTANTE

Publication

EP 1073423 A1 (EN)

Application

EP 99912841 A

Priority

  • US 9906339 W
  • US 4786398 A

Abstract (en)

[origin: WO9948481A1] A tablet for the controlled release of an active pharmaceutical ingredient. The tablet comprises a core having a donut-like configuration with a cylindrical hole extending through the center of the core. The core of the body comprises at least one active pharmaceutical agent and at least one hydrophilic, water-soluble, polymeric carrier. The core is coated with a hydrophobic, water-insoluble material covering all of the core except that which is defined by the cylindrical hole. Also included is a method of preparing a tablet for the controlled release of an active ingredient. The method comprises the steps of blending an active pharmaceutical ingredient, a water-soluble hydrophilic, polymeric carrier, and optionally an excipient, to form a mix; compressing the mix; punching a tablet from the mix; coating the tablet in a water insoluble, hydrophobic coating, then drilling a hole through the coated tablet. A second embodiment of this method includes drilling a first hole through the tablet before coating the tablet, placing a rod through the first hole, dipping the tablet into the coating, and then removing the rod and drilling a second hole in the tablet which is larger than the first hole.

IPC 1-7 (main, further and additional classification)

A61K 9/34

IPC 8 full level (invention and additional information)

A61K 9/20 (2006.01); A61K 9/36 (2006.01)

CPC (invention and additional information)

A61K 9/2072 (2013.01)

Citation (search report)

See references of WO 9948481A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9948481 A1 19990930; AU 3111799 A 19991018; EP 1073423 A1 20010207; US 6110500 A 20000829

INPADOC legal status


2005-04-27 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20041002

2001-02-07 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20001024

2001-02-07 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE