Global Patent Index - EP 1073425 A1

EP 1073425 A1 2001-02-07 - FIBRINOGEN COATED DROPLETS OF LIQUID HYDROPHOBIC PHASES

Title (en)

FIBRINOGEN COATED DROPLETS OF LIQUID HYDROPHOBIC PHASES

Title (de)

FIBRINOGEN UMHÜLLTE TRÖPFCHEN VON FLÜSSIGE HYDROPHOBE PHASEN

Title (fr)

GOUTTELETTES, ENROBEES DE FIBRINOGENE, DE PHASES HYDROPHOBES LIQUIDES

Publication

EP 1073425 A1 (EN)

Application

EP 99921733 A

Priority

  • US 9909940 W
  • US 8370998 P

Abstract (en)

[origin: WO9955314A1] Fibrinogen adsorbs spontaneously from aqueous media containing that protein to droplets of liquid hydrophobic phases dispersed in those same media. Examples of such phases include mineral oils, straight chain hydrocarbons, and various plant- and animal-derived oils. Lecithin preexisting on the surface of oil droplets reduces significantly the amount of fibrinogen that can otherwise bind to them. When bound, fibrinogen remains active in the classic sense of fibrin gelation. As a consequence, oil droplets coated with fibrinogen can participate in a host of biologically important adhesive processes in which the protein would be expected to participate. Certain polyanions, e.g., heparin, pentosan polysulfate, dextran sulfate and suramin, bind to adsorbed fibrin(ogen) and prevent thrombin-dependent adhesion of fibrinogen-coated surfaces. Thus, these polyanions can be used to prevent adhesion between fibrin(ogen)-coated oil droplets and other fibrin(ogen)-coated surfaces. Potential practical applications and biological implications of these phenomena are presented and discussed.

IPC 1-7 (main, further and additional classification)

A61K 9/50; A61K 9/16

IPC 8 full level (invention and additional information)

A61K 9/107 (2006.01); A61K 9/127 (2006.01); A61K 9/50 (2006.01)

CPC (invention and additional information)

A61K 9/127 (2013.01); A61K 9/107 (2013.01); A61K 9/5052 (2013.01)

Citation (search report)

See references of WO 9955314A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9955314 A1 19991104; CA 2327469 A1 19991104; EP 1073425 A1 20010207

INPADOC legal status


2002-05-22 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20011101

2002-01-16 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20011130

2001-02-07 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20001123

2001-02-07 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE