Global patent index - EP 1073633 A2

EP 1073633 A2 2001-02-07 - SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2

Title (en)

SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2

Title (de)

SUBSTITUIERTE BETA-AMINOSÄUREN ALS INHIBITOREN DER METHIONIN AMINOPEPTIDASE-2

Title (fr)

INHIBITEURS $g(b)-AMINO-ACIDE SUBSTITUES DE LA METHIONINE AMINOPEPTIDASE-2

Publication

EP 1073633 A2 (EN)

Application

EP 99921611 A

Priority

  • US 9909641 W
  • US 7171498 A

Abstract (en)

[origin: CA2329704A1] A class of substituted .beta.-amino acids are potent inhibitors of methionin e aminopeptidase type 2 (MetAP2) and are thus useful in inhibiting angiogenesi s and disease conditions which depend upon angiogenesis for their development such as diabetic retinopathy, tumor growth, and conditions of inflammation. Pharmaceutical compounds containing the compounds and methods of inhibiting methionine aminopeptidase-2, and angiogenesis are also disclosed.

[origin: CA2329704A1] A class of substituted .beta.-amino acids are potent inhibitors of methionine aminopeptidase type 2 (MetAP2) and are thus useful in inhibiting angiogenesis and disease conditions which depend upon angiogenesis for their development such as diabetic retinopathy, tumor growth, and conditions of inflammation. Pharmaceutical compounds containing the compounds and methods of inhibiting methionine aminopeptidase-2, and angiogenesis are also disclosed.

IPC 1-7 (main, further and additional classification)

C07C 323/60; A61K 31/16; C07C 235/16; C07C 237/12; C07C 237/14; C07C 311/19; C07D 295/185

IPC 8 full level (invention and additional information)

C07D 295/12 (2006.01); A61K 31/16 (2006.01); A61K 31/18 (2006.01); A61K 31/198 (2006.01); A61K 31/22 (2006.01); A61K 31/221 (2006.01); A61K 31/223 (2006.01); A61K 31/341 (2006.01); A61K 31/357 (2006.01); A61K 31/36 (2006.01); A61K 31/381 (2006.01); A61K 31/40 (2006.01); A61K 31/4015 (2006.01); A61K 31/403 (2006.01); A61K 31/4035 (2006.01); A61K 31/404 (2006.01); A61K 31/4045 (2006.01); A61K 31/415 (2006.01); A61K 31/4164 (2006.01); A61K 31/4166 (2006.01); A61K 31/4184 (2006.01); A61K 31/426 (2006.01); A61K 31/4402 (2006.01); A61K 31/4406 (2006.01); A61K 31/4409 (2006.01); A61K 31/4418 (2006.01); A61K 31/4468 (2006.01); A61K 31/451 (2006.01); A61K 31/454 (2006.01); A61K 31/472 (2006.01); A61K 31/5355 (2006.01); A61K 31/5375 (2006.01); A61K 31/55 (2006.01); A61P 9/00 (2006.01); A61P 19/02 (2006.01); A61P 27/02 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); C07C 235/16 (2006.01); C07C 237/12 (2006.01); C07C 237/14 (2006.01); C07C 311/19 (2006.01); C07C 323/60 (2006.01); C07D 207/27 (2006.01); C07D 209/16 (2006.01); C07D 209/48 (2006.01); C07D 211/58 (2006.01); C07D 211/82 (2006.01); C07D 213/40 (2006.01); C07D 213/61 (2006.01); C07D 213/74 (2006.01); C07D 217/06 (2006.01); C07D 231/12 (2006.01); C07D 231/40 (2006.01); C07D 233/61 (2006.01); C07D 233/72 (2006.01); C07D 233/95 (2006.01); C07D 235/14 (2006.01); C07D 265/30 (2006.01); C07D 277/20 (2006.01); C07D 277/46 (2006.01); C07D 277/56 (2006.01); C07D 295/18 (2006.01); C07D 295/185 (2006.01); C07D 307/10 (2006.01); C07D 307/52 (2006.01); C07D 317/58 (2006.01); C07D 319/18 (2006.01); C07D 333/20 (2006.01); C07D 333/38 (2006.01)

IPC 8 main group level (invention and additional information)

C07C (2006.01)

CPC (invention and additional information)

Y02P 20/55 (2015.11)

Citation (search report)

See references of WO 9957098A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

AU 3877899 A 19991123; CA 2329704 A1 19991111; CN 1308608 A 20010815; CO 5021134 A1 20010327; EP 1073633 A2 20010207; IL 139139 D0 20011125; JP 2002513781 A 20020514; PL 346444 A1 20020211

INPADOC legal status

2007-12-07 [REG HK WD] APPLICATIONS WITHDRAWN, DEEMED TO BE WITHDRAWN, OR REFUSED AFTER PUBLICATION IN HONG KONG

- Ref Legal Event Code: WD

- Ref Document Number: 1037174

- Country of Ref Document: HK

2003-02-05 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20020801

2002-03-06 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20020121

2001-02-07 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20001030

2001-02-07 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2001-02-07 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Ref Legal Event Code: AX

- Free Format Text: RO PAYMENT 20001030;SI PAYMENT 20001030