Global Patent Index - EP 1073748 A2

EP 1073748 A2 2001-02-07 - VACCINES CONTAINING RECOMBINANT PILIN AGAINST NEISSERIA GONORRHOEAE OR NEISSERIA MENINGITIDIS

Title (en)

VACCINES CONTAINING RECOMBINANT PILIN AGAINST NEISSERIA GONORRHOEAE OR NEISSERIA MENINGITIDIS

Title (de)

IMPSTOFFE DIE REKOMBINANTES PILIN GEGEN NEISSERIA GONORRHOEAE ODER NEISSERIA MENINGITIDIS ENTHALTEN

Title (fr)

VACCINS CONTENANT DE LA PILINE DE RECOMBINAISON UTILISES CONTRE LES MALADIES PROVOQUEES PAR $i(NEISSERIA GONORRHOEAE) OU $i(NEISSERIA MENINGITIDIS)

Publication

EP 1073748 A2 (EN)

Application

EP 99922760 A

Priority

  • US 9909486 W
  • US 8340598 P

Abstract (en)

[origin: WO9955875A2] The pilE genes of each of Neisseria gonorrhoeae and Neisseria meningitidis are cloned and their corresponding recombinant pilin proteins are expressed. In addition, a chimeric pilE gene is constructed in which the region of the pilE gene of Neisseria meningitidis class I encoding the amino-terminal region of the pilin protein is replaced by the corresponding region of the pilE gene of Neisseria gonorrhoeae. The recombinant meningococcal chimeric class I pilin protein is expressed at higher levels than the pilin protein expressed by the full-length pilE gene of Neisseria meningitidis. Furthermore, a chimeric pilE gene is constructed in which the region of the pilE gene of Neisseria meningitidis class II encoding the carboxy-terminal region of the pilin protein is replaced by the corresponding region of the pilE gene of Neisseria gonorrhoeae. The recombinant pilin proteins are used in vaccines to protect against disease caused by Neisseria gonorrhoeae or Neisseria meningitidis.

IPC 1-7 (main, further and additional classification)

C12N 15/31; A61K 39/095; C07K 14/22; C07K 19/00; C12N 15/62

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 39/095 (2006.01); A61P 31/04 (2006.01); C07K 14/22 (2006.01); C07K 19/00 (2006.01); C12N 1/21 (2006.01); C12N 15/31 (2006.01); C12P 21/02 (2006.01); A61K 39/00 (2006.01)

CPC (invention and additional information)

C07K 14/22 (2013.01); A61K 39/00 (2013.01); C07K 2319/02 (2013.01)

Citation (search report)

See references of WO 9955875A3

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9955875 A2 19991104; WO 9955875 A3 20000413; AU 2003204738 B2 20060914; AU 3968599 A 19991116; BR 9910005 A 20010116; CA 2325055 A1 19991104; CN 1245512 C 20060315; CN 1298446 A 20010606; EP 1073748 A2 20010207; IL 139311 D0 20011125; JP 2002527041 A 20020827; KR 20060118628 A 20061123; KR 20060118629 A 20061123; KR 20060118630 A 20061123

INPADOC legal status


2008-08-06 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20080209

2005-05-25 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20050411

2003-05-02 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: WYETH HOLDINGS CORPORATION

2001-02-07 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20001012

2001-02-07 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE