EP 1073748 A2 20010207 - VACCINES CONTAINING RECOMBINANT PILIN AGAINST NEISSERIA GONORRHOEAE OR NEISSERIA MENINGITIDIS
Title (en)
VACCINES CONTAINING RECOMBINANT PILIN AGAINST NEISSERIA GONORRHOEAE OR NEISSERIA MENINGITIDIS
Title (de)
IMPSTOFFE DIE REKOMBINANTES PILIN GEGEN NEISSERIA GONORRHOEAE ODER NEISSERIA MENINGITIDIS ENTHALTEN
Title (fr)
VACCINS CONTENANT DE LA PILINE DE RECOMBINAISON UTILISES CONTRE LES MALADIES PROVOQUEES PAR $i(NEISSERIA GONORRHOEAE) OU $i(NEISSERIA MENINGITIDIS)
Publication
Application
Priority
- US 9909486 W 19990429
- US 8340598 P 19980429
Abstract (en)
[origin: WO9955875A2] The pilE genes of each of Neisseria gonorrhoeae and Neisseria meningitidis are cloned and their corresponding recombinant pilin proteins are expressed. In addition, a chimeric pilE gene is constructed in which the region of the pilE gene of Neisseria meningitidis class I encoding the amino-terminal region of the pilin protein is replaced by the corresponding region of the pilE gene of Neisseria gonorrhoeae. The recombinant meningococcal chimeric class I pilin protein is expressed at higher levels than the pilin protein expressed by the full-length pilE gene of Neisseria meningitidis. Furthermore, a chimeric pilE gene is constructed in which the region of the pilE gene of Neisseria meningitidis class II encoding the carboxy-terminal region of the pilin protein is replaced by the corresponding region of the pilE gene of Neisseria gonorrhoeae. The recombinant pilin proteins are used in vaccines to protect against disease caused by Neisseria gonorrhoeae or Neisseria meningitidis.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 39/095 (2006.01); A61P 31/04 (2006.01); C07K 14/22 (2006.01); C07K 19/00 (2006.01); C12N 1/21 (2006.01); C12N 15/31 (2006.01); C12P 21/02 (2006.01); A61K 39/00 (2006.01)
CPC (source: EP KR US)
A61P 31/04 (2018.01 - EP); C07K 14/22 (2013.01 - EP); C12N 15/11 (2013.01 - KR); A61K 39/00 (2013.01 - EP KR US); C07K 2319/02 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9955875 A2 19991104; WO 9955875 A3 20000413; AU 2003204738 B2 20060914; AU 3968599 A 19991116; BR 9910005 A 20010116; CA 2325055 A1 19991104; CN 1245512 C 20060315; CN 1298446 A 20010606; EP 1073748 A2 20010207; IL 139311 A0 20011125; JP 2002527041 A 20020827; KR 20010043105 A 20010525; KR 20060118628 A 20061123; KR 20060118629 A 20061123; KR 20060118630 A 20061123
DOCDB simple family (application)
US 9909486 W 19990429; AU 2003204738 A 20030616; AU 3968599 A 19990429; BR 9910005 A 19990429; CA 2325055 A 19990429; CN 99805601 A 19990429; EP 99922760 A 19990429; IL 13931199 A 19990429; JP 2000546019 A 19990429; KR 20007011991 A 20001027; KR 20067022726 A 20061030; KR 20067022728 A 20061030; KR 20067022731 A 20061030