Global Patent Index - EP 1075184 A1

EP 1075184 A1 2001-02-14 - METHOD FOR ACTIVE VACCINATION AGASINT CD20

Title (en)

METHOD FOR ACTIVE VACCINATION AGASINT CD20

Title (de)

VERFAHREN ZUR AKTIVEN IMPFUNG GEGEN CD20

Title (fr)

PROCEDE DE VACCINATION ACTIVE CONTRE CD20

Publication

EP 1075184 A1 (EN)

Application

EP 99921790 A

Priority

  • US 9910065 W
  • US 8487098 P

Abstract (en)

[origin: WO9957981A1] Non-Hodgkin's lymphoma (NHL) is treated, not by administration of an anti-CD20 monoclonal antibody, but by the administration of CD20 itself, or an immunogenic fragment of the extracellular portion thereof, coupled to or administered with an antigenic carrier moiety such as keyhole limpet hemocyanin (KLH). This results in the stimulation of the production of polyclonal antibodies against CD20 (or an immunogenic fragment thereof) which has the effect of reducing the number of B-cells, including malignant B-cells, and thus provides an active vaccine. The same approach can be used for therapeutics for other diseases and conditions in which target cells possess a transmembrane protein, and is particularly applicable to those diseases and conditions for which administration of antibodies to transmembrane proteins or peptides (i.e., passive therapy) have been shown to provide therapeutic benefits, and especially in the situations where the target is also capable of transducing or receiving a signal important for cell growth or function. This would include, for example, Her2/neu, VEGF receptor, epidermal growth factor receptor, the CD19 molecule, interleukin-2-receptor, interleukin-4-receptor, and the P-glycoprotein, also known as the multidrug-resistance protein.

IPC 1-7 (main, further and additional classification)

A01N 37/18

IPC 8 full level (invention and additional information)

A61K 39/385 (2006.01); A61K 39/00 (2006.01); A61K 39/39 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01)

CPC (invention and additional information)

A61K 39/0011 (2013.01); A61K 2039/55577 (2013.01); A61K 2039/6081 (2013.01)

Designated contracting state (EPC)

DE DK ES FR GB IT SE

EPO simple patent family

WO 9957981 A1 19991118; CA 2330212 A1 19991118; EP 1075184 A1 20010214; EP 1075184 A4 20020130; JP 2002514573 A 20020521

INPADOC legal status


2007-05-23 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20061201

2005-10-05 [RTI1] TITLE (CORRECTION)

- Free text: METHOD FOR ACTIVE VACCINATION AGAINST CD20

2005-08-31 [RTI1] TITLE (CORRECTION)

- Free text: METHOD FOR ACTIVE VACCINATION AGASINT CD20

2002-11-13 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20020927

2002-01-30 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20011218

2002-01-30 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): DE DK ES FR GB IT SE

2002-01-09 [RIC1] CLASSIFICATION (CORRECTION)

- Free text: 7A 01N 37/18 A, 7A 61K 39/00 B, 7A 61K 39/385 B, 7A 61P 35/00 B, 7C 07K 14/705 -

2001-02-14 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20001204

2001-02-14 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): DE DK ES FR GB IT SE