EP 1075184 A1 20010214 - METHOD FOR ACTIVE VACCINATION AGASINT CD20
Title (en)
METHOD FOR ACTIVE VACCINATION AGASINT CD20
Title (de)
VERFAHREN ZUR AKTIVEN IMPFUNG GEGEN CD20
Title (fr)
PROCEDE DE VACCINATION ACTIVE CONTRE CD20
Publication
Application
Priority
- US 9910065 W 19990507
- US 8487098 P 19980508
Abstract (en)
[origin: WO9957981A1] Non-Hodgkin's lymphoma (NHL) is treated, not by administration of an anti-CD20 monoclonal antibody, but by the administration of CD20 itself, or an immunogenic fragment of the extracellular portion thereof, coupled to or administered with an antigenic carrier moiety such as keyhole limpet hemocyanin (KLH). This results in the stimulation of the production of polyclonal antibodies against CD20 (or an immunogenic fragment thereof) which has the effect of reducing the number of B-cells, including malignant B-cells, and thus provides an active vaccine. The same approach can be used for therapeutics for other diseases and conditions in which target cells possess a transmembrane protein, and is particularly applicable to those diseases and conditions for which administration of antibodies to transmembrane proteins or peptides (i.e., passive therapy) have been shown to provide therapeutic benefits, and especially in the situations where the target is also capable of transducing or receiving a signal important for cell growth or function. This would include, for example, Her2/neu, VEGF receptor, epidermal growth factor receptor, the CD19 molecule, interleukin-2-receptor, interleukin-4-receptor, and the P-glycoprotein, also known as the multidrug-resistance protein.
IPC 1-7
IPC 8 full level
A61K 39/385 (2006.01); A61K 39/00 (2006.01); A61K 39/39 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01)
CPC (source: EP US)
A61K 39/0011 (2013.01 - EP US); A61K 39/001104 (2018.08 - EP US); A61K 39/001106 (2018.08 - EP US); A61K 39/001109 (2018.08 - EP US); A61K 39/001112 (2018.08 - EP US); A61K 39/001119 (2018.08 - EP US); A61K 39/001124 (2018.08 - EP US); A61P 35/00 (2018.01 - EP); A61P 43/00 (2018.01 - EP); A61K 2039/55577 (2013.01 - EP); A61K 2039/6081 (2013.01 - EP); A61K 2039/70 (2013.01 - EP US)
Designated contracting state (EPC)
DE DK ES FR GB IT SE
DOCDB simple family (publication)
WO 9957981 A1 19991118; CA 2330212 A1 19991118; EP 1075184 A1 20010214; EP 1075184 A4 20020130; JP 2002514573 A 20020521
DOCDB simple family (application)
US 9910065 W 19990507; CA 2330212 A 19990507; EP 99921790 A 19990507; JP 2000547851 A 19990507