EP 1075267 A2 20010214 - TREATMENT OF CELIAC DISEASE
Title (en)
TREATMENT OF CELIAC DISEASE
Title (de)
BEHANDLUNG DER ZÖLIAKIE (EINHEIMISCHE SPRUE)
Title (fr)
TRAITEMENT DE LA MALADIE CAELIAQUE
Publication
Application
Priority
- DK 9900255 W 19990506
- DK 62198 A 19980506
- US 9154598 P 19980701
Abstract (en)
[origin: WO9956698A2] The present invention relates to a method of treating celiac disease comprising interfering with the deamidation of at least one glutamine residue in a gliadin or glutenin molecule. This may be provided by prohibiting or interfering with the deamidation of at least one glutamine residue by derivation of at least one glutamine residue in a gliadin or glutenine molecule in wheat flour by a chemical or enzymatic deamidation of gluten followed by chemical or enzymatic derivation of the generated carboxyl group(s). In a further aspect, the invention relates to a method of interfering with the deamidation of at least one glutamine residue in a gliadin or glutenin molecule and thereby treating celiac disease, the method comprising administering, to a patient having or suspected of having celiac disease, at least one of the following substances: (a) a substance which is capable of increasing the pH in the gastroduodenal tract of a subject, e.g. an antacidum, an anticholinergic agent, H2-receptor antagonists or a proton pump inhibitor, (b) a substance which is capable of eliminating deamidating bacteria in the gastroduodenal tract of a subject, e.g. an antibiotic or antimicrobial agent, and/or (c) a substance which is capable of interfering with the effect of at least one deamidating enzyme in the gastroduodenal tract of a subject.
IPC 1-7
A61K 33/06; A61K 33/10; A61K 33/08; A61K 33/12; A61K 31/34; A61K 31/415; A61K 31/44; A61K 31/35; A61K 31/435
IPC 8 full level
A61K 31/341 (2006.01); A61K 31/352 (2006.01); A61K 31/4164 (2006.01); A61K 31/426 (2006.01); A61K 31/439 (2006.01); A61K 31/4439 (2006.01); A61K 33/06 (2006.01); A61K 33/08 (2006.01); A61K 33/10 (2006.01); A61K 33/12 (2006.01)
CPC (source: EP)
A61K 31/341 (2013.01); A61K 31/352 (2013.01); A61K 31/4164 (2013.01); A61K 31/426 (2013.01); A61K 31/439 (2013.01); A61K 31/4439 (2013.01); A61K 33/06 (2013.01); A61K 33/08 (2013.01); A61K 33/10 (2013.01); A61K 33/12 (2013.01)
Citation (search report)
See references of WO 9956698A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9956698 A2 19991111; WO 9956698 A3 19991229; AU 3596199 A 19991123; EP 1075267 A2 20010214
DOCDB simple family (application)
DK 9900255 W 19990506; AU 3596199 A 19990506; EP 99917810 A 19990506