Global Patent Index - EP 1075267 A2

EP 1075267 A2 2001-02-14 - TREATMENT OF CELIAC DISEASE

Title (en)

TREATMENT OF CELIAC DISEASE

Title (de)

BEHANDLUNG DER ZÖLIAKIE (EINHEIMISCHE SPRUE)

Title (fr)

TRAITEMENT DE LA MALADIE CAELIAQUE

Publication

EP 1075267 A2 (EN)

Application

EP 99917810 A

Priority

  • DK 9900255 W
  • DK 62198 A
  • US 9154598 P

Abstract (en)

[origin: WO9956698A2] The present invention relates to a method of treating celiac disease comprising interfering with the deamidation of at least one glutamine residue in a gliadin or glutenin molecule. This may be provided by prohibiting or interfering with the deamidation of at least one glutamine residue by derivation of at least one glutamine residue in a gliadin or glutenine molecule in wheat flour by a chemical or enzymatic deamidation of gluten followed by chemical or enzymatic derivation of the generated carboxyl group(s). In a further aspect, the invention relates to a method of interfering with the deamidation of at least one glutamine residue in a gliadin or glutenin molecule and thereby treating celiac disease, the method comprising administering, to a patient having or suspected of having celiac disease, at least one of the following substances: (a) a substance which is capable of increasing the pH in the gastroduodenal tract of a subject, e.g. an antacidum, an anticholinergic agent, H2-receptor antagonists or a proton pump inhibitor, (b) a substance which is capable of eliminating deamidating bacteria in the gastroduodenal tract of a subject, e.g. an antibiotic or antimicrobial agent, and/or (c) a substance which is capable of interfering with the effect of at least one deamidating enzyme in the gastroduodenal tract of a subject.

IPC 1-7 (main, further and additional classification)

A61K 33/06; A61K 31/34; A61K 31/35; A61K 31/415; A61K 31/435; A61K 31/44; A61K 33/08; A61K 33/10; A61K 33/12

IPC 8 full level (invention and additional information)

A61K 31/341 (2006.01); A61K 31/352 (2006.01); A61K 31/4164 (2006.01); A61K 31/426 (2006.01); A61K 31/439 (2006.01); A61K 31/4439 (2006.01); A61K 33/06 (2006.01); A61K 33/08 (2006.01); A61K 33/10 (2006.01); A61K 33/12 (2006.01)

CPC (invention and additional information)

A61K 31/341 (2013.01); A61K 31/352 (2013.01); A61K 31/4164 (2013.01); A61K 31/426 (2013.01); A61K 31/439 (2013.01); A61K 31/4439 (2013.01); A61K 33/06 (2013.01); A61K 33/08 (2013.01); A61K 33/10 (2013.01); A61K 33/12 (2013.01)

Citation (search report)

See references of WO 9956698A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9956698 A2 19991111; WO 9956698 A3 19991229; AU 3596199 A 19991123; EP 1075267 A2 20010214

INPADOC legal status


2002-06-05 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20011127

2001-06-27 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20010514

2001-02-14 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20001206

2001-02-14 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE