Global Patent Index - EP 1075276 A2

EP 1075276 A2 2001-02-14 - ADJUVANT COMPOSITION AND METHODS FOR ITS USE

Title (en)

ADJUVANT COMPOSITION AND METHODS FOR ITS USE

Title (de)

ADJUVANSZUSAMMENSETZUNG UND METHODEN ZU DEREN VERWENDNG

Title (fr)

COMPOSITION D'ADJUVANT ET PROCEDES D'UTILISATION DE CELLE-CI

Publication

EP 1075276 A2 (EN)

Application

EP 99922832 A

Priority

  • US 9909978 W
  • US 8467898 P

Abstract (en)

[origin: WO9956776A2] An adjuvant composition which is a stable oil-in-water emulsion comprising a metabolizable oil, one or more surfactants, an antioxidant and a compound to make the emulsion isotonic is described and claimed. The stable emulsion has a hydrophobic-lipophilic balance (HLB) of from about 7.5 to about 10.5 and a particle size of less than 3 mu m. In a preferred embodiment, the stable emulsion comprises 10 % volume to volume squalene, 0.09 % weight to volume PLURONIC F-68 block co-polymer, 1.9 % weight to volume egg phosphatidyl choline, 1.75 % volume to volume glycerol and 0.05 % weight to volume alpha tocopherol. The preferred emulsion has a HLB of 8.0 and a particle size of about 0.2 mu m. In a particularly preferred embodiment, the stable emulsion is combined with an attenuated lipid A derivative such as monophosphoryl lipid A or 3-deacylated monophosphoryl lipid A to enhance the adjuvanticity of the composition.

IPC 1-7 (main, further and additional classification)

A61K 39/39; A61K 39/00

IPC 8 full level (invention and additional information)

A61K 47/44 (2006.01); A61K 9/66 (2006.01); A61K 39/00 (2006.01); A61K 39/39 (2006.01); A61P 37/04 (2006.01)

CPC (invention and additional information)

A61K 39/39 (2013.01); A61K 2039/55566 (2013.01); A61K 2039/55572 (2013.01)

Citation (search report)

See references of WO 9956776A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9956776 A2 19991111; WO 9956776 A3 20000106; AT 375803 T 20071115; AU 3973799 A 19991123; AU 755445 B2 20021212; BR 9910269 A 20010109; CA 2330610 A1 19991111; CN 101219217 A 20080716; CN 1306438 A 20010801; CY 1107265 T1 20121121; DE 69937343 D1 20071129; DE 69937343 T2 20080724; DK 1075276 T3 20080211; EP 1075276 A2 20010214; EP 1075276 B1 20071017; ES 2296390 T3 20080416; HU 0101804 A2 20011128; HU 0101804 A3 20031128; HU 225844 B1 20071029; JP 2002513773 A 20020514; NO 20005596 A 20010105; NO 20005596 D0 20001106; NZ 508013 A 20030829; PT 1075276 E 20080122; US 2003215497 A1 20031120; US 6630161 B1 20031007; ZA 200006379 B 20020107

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