Global Patent Index - EP 1075279 A2

EP 1075279 A2 2001-02-14 - SYNTHETIC POLYAMINOACID COMPLEXES FOR DELIVERY OF NUCLEIC ACIDS TO TARGET CELLS

Title (en)

SYNTHETIC POLYAMINOACID COMPLEXES FOR DELIVERY OF NUCLEIC ACIDS TO TARGET CELLS

Title (de)

SYNTHETISCHE POLYAMIOSAURE KOMPLEXEN ZUR VERABREICHUNG VON NUKLEINSÄUREN ZUR ZIELZELLEN

Title (fr)

SYSTEME POLYMERE AUX FINS DE L'APPORT D'ACIDE NUCLEIQUE A DES CELLULES CIBLES DANS DES SYSTEMES BIOLOGIQUES

Publication

EP 1075279 A2 (EN)

Application

EP 99917692 A

Priority

  • EP 99917692 A
  • BE 9900056 W
  • EP 98201454 A
  • EP 98201566 A

Abstract (en)

[origin: WO9958151A2] A synthetic polymer-based carrier vehicle and a method of constructing the synthetic polymer-based carrier vehicle for delivery of nucleic acid material to target cells in biological systems are described. The method comprising the steps of: a) providing a cationic polyelectrolyte polymer material including a (I) derivative of an amino acid or a synthetic amino acid, or a vinyl-type polymer; and b) bringing the nucleic acid material into association with said cationic polyelectrolyte polymer material to form by self-assembly therebetween a polyelectrolyte complex which provides a nucleic acid containing cationic polymer core for said carrier vehicle. The synthetic polymer-based carrier vehicle includes the amino acid derivative or the vinyl type polymer made by the method. The derivative is preferably a polyglutamine or polyasparagine derivative.

IPC 1-7 (main, further and additional classification)

A61K 47/48

IPC 8 full level (invention and additional information)

A61K 47/48 (2006.01); A61K 48/00 (2006.01)

CPC (invention and additional information)

A61K 47/48315 (2013.01); A61K 48/00 (2013.01)

Citation (search report)

See references of WO 9958151A3

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9958151 A2 19991118; WO 9958151 A3 20000413; AU 3589699 A 19991129; AU 757982 B2 20030313; CA 2331840 A1 19991118; EP 0963758 A2 19991215; EP 0963758 A3 20000322; EP 1075279 A2 20010214

INPADOC legal status


2004-06-16 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20031201

2001-02-14 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20001109

2001-02-14 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE