EP 1075524 A2 20010214 - ATTENUATED INFLUENZA VIRUSES
Title (en)
ATTENUATED INFLUENZA VIRUSES
Title (de)
ATTENUIERTE INFLUENZA VIREN
Title (fr)
VIRUS ATTENUE DE LA GRIPPE
Publication
Application
Priority
- GB 9901413 W 19990506
- GB 9809666 A 19980506
Abstract (en)
[origin: WO9957284A2] An attenuated influenza virus carrying a genomic nucleic acid segment which comprises 5' and 3' non-coding regions providing a mutated duplex region of an influenza virus RNA genomic segment operably-linked to a protein coding sequence for an influenza viral protein or a functional modification thereof, wherein said duplex region has at least one base-pair substitution such that expression of said protein-coding sequence in cells infected by said virus is reduced to give an attenuated phenotype. The attenuated influenza virus can be used in a vaccine.
IPC 1-7
IPC 8 full level
A61K 39/145 (2006.01); A61P 31/16 (2006.01); C07K 14/11 (2006.01); C12N 5/10 (2006.01); C12N 7/00 (2006.01); C12N 7/04 (2006.01); C12N 15/09 (2006.01); C12N 15/44 (2006.01); C12N 15/86 (2006.01)
CPC (source: EP)
A61K 39/12 (2013.01); A61K 39/145 (2013.01); A61P 31/16 (2017.12); C07K 14/005 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); A61K 2039/5254 (2013.01); C12N 2760/16022 (2013.01); C12N 2760/16043 (2013.01); C12N 2760/16061 (2013.01); C12N 2760/16134 (2013.01)
Citation (search report)
See references of WO 9957284A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9957284 A2 19991111; WO 9957284 A3 19991229; AU 3723099 A 19991123; CA 2327584 A1 19991111; EP 1075524 A2 20010214; GB 9809666 D0 19980701; JP 2002513575 A 20020514
DOCDB simple family (application)
GB 9901413 W 19990506; AU 3723099 A 19990506; CA 2327584 A 19990506; EP 99919444 A 19990506; GB 9809666 A 19980506; JP 2000547239 A 19990506