Global patent index - EP 1075524 A2

EP 1075524 A2 2001-02-14 - ATTENUATED INFLUENZA VIRUSES

Title (en)

ATTENUATED INFLUENZA VIRUSES

Title (de)

ATTENUIERTE INFLUENZA VIREN

Title (fr)

VIRUS ATTENUE DE LA GRIPPE

Publication

EP 1075524 A2 (EN)

Application

EP 99919444 A

Priority

  • GB 9901413 W
  • GB 9809666 A

Abstract (en)

[origin: WO9957284A2] An attenuated influenza virus carrying a genomic nucleic acid segment which comprises 5' and 3' non-coding regions providing a mutated duplex region of an influenza virus RNA genomic segment operably-linked to a protein coding sequence for an influenza viral protein or a functional modification thereof, wherein said duplex region has at least one base-pair substitution such that expression of said protein-coding sequence in cells infected by said virus is reduced to give an attenuated phenotype. The attenuated influenza virus can be used in a vaccine.

IPC 1-7 (main, further and additional classification)

C12N 15/44; A61K 39/145; C12N 7/01; C12N 15/86

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 39/145 (2006.01); A61P 31/16 (2006.01); C07K 14/11 (2006.01); C12N 5/10 (2006.01); C12N 7/00 (2006.01); C12N 7/04 (2006.01); C12N 15/44 (2006.01); C12N 15/86 (2006.01)

CPC (invention and additional information)

A61K 39/145 (2013.01); A61K 39/12 (2013.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); A61K 2039/5254 (2013.01); C12N 2760/16022 (2013.01); C12N 2760/16043 (2013.01); C12N 2760/16061 (2013.01); C12N 2760/16134 (2013.01)

Citation (search report)

See references of WO 9957284A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9957284 A2 19991111; WO 9957284 A3 19991229; AU 3723099 A 19991123; CA 2327584 A1 19991111; EP 1075524 A2 20010214; GB 9809666 D0 19980701; JP 2002513575 A 20020514

INPADOC legal status

2007-05-30 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20061201

2003-09-24 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20030808

2001-02-14 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20001204

2001-02-14 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE