EP 1075532 A1 20010214 - PARTIALLY DELETED ADENOVIRAL VECTORS
Title (en)
PARTIALLY DELETED ADENOVIRAL VECTORS
Title (de)
TEILWEISE DELETIERTE ADENOVIRUSVEKTOREN
Title (fr)
VECTEURS ADENOVIRAUX A DELETION PARTIELLE
Publication
Application
Priority
- US 9909590 W 19990430
- US 8384198 P 19980501
- US 11811899 P 19990201
Abstract (en)
[origin: CA2328087A1] The invention is directed to novel partially deleted adenoviral vectors (DeAd) in which the majority of adenoviral early genes required for replication are deleted from the vector and placed within the chromosome of a producer cell line under conditional promoter control. The partially deleted adenoviral (DeAd) vectors of the invention can accommodate inserts, such as transgenes, of up to 12-15 kb in size. The invention is further directed to DeAd vector producer cell lines that contain the adenoviral early genes necessary for replication under conditional promoter control that allow for large scale production of vectors. The invention is also directed to methods for the production of DeAd vectors in such cell lines and to the use of such vectors to deliver transgenes to target cells.
[origin: CA2328087A1] The invention is directed to novel partially deleted adenoviral vectors (DeA d) in which the majority of adenoviral early genes required for replication are deleted from the vector and placed within the chromosome of a producer cell line under conditional promoter control. The partially deleted adenoviral (DeAd) vectors of the invention can accommodate inserts, such as transgenes, of up to 12-15 kb in size. The invention is further directed to DeAd vector producer cell lines that contain the adenoviral early genes necessary for replication under conditional promoter control that allow for large scale production of vectors. The invention is also directed to methods for the production of DeAd vectors in such cell lines and to the use of such vectors to deliver transgenes to target cells.
IPC 1-7
IPC 8 full level
C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 7/00 (2006.01); C12N 15/09 (2006.01); C12N 15/86 (2006.01); C12R 1/93 (2006.01)
Citation (search report)
See references of WO 9957296A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
AU 3877099 A 19991123; CA 2328087 A1 19991111; EP 1075532 A1 20010214; JP 2002513582 A 20020514
DOCDB simple family (application)
AU 3877099 A 19990430; CA 2328087 A 19990430; EP 99921601 A 19990430; JP 2000547249 A 19990430