Global patent index - EP 1075532 A1

EP 1075532 A1 2001-02-14 - PARTIALLY DELETED ADENOVIRAL VECTORS

Title (en)

PARTIALLY DELETED ADENOVIRAL VECTORS

Title (de)

TEILWEISE DELETIERTE ADENOVIRUSVEKTOREN

Title (fr)

VECTEURS ADENOVIRAUX A DELETION PARTIELLE

Publication

EP 1075532 A1 (EN)

Application

EP 99921601 A

Priority

  • US 9909590 W
  • US 8384198 P
  • US 11811899 P

Abstract (en)

[origin: CA2328087A1] The invention is directed to novel partially deleted adenoviral vectors (DeA d) in which the majority of adenoviral early genes required for replication are deleted from the vector and placed within the chromosome of a producer cell line under conditional promoter control. The partially deleted adenoviral (DeAd) vectors of the invention can accommodate inserts, such as transgenes, of up to 12-15 kb in size. The invention is further directed to DeAd vector producer cell lines that contain the adenoviral early genes necessary for replication under conditional promoter control that allow for large scale production of vectors. The invention is also directed to methods for the production of DeAd vectors in such cell lines and to the use of such vectors to deliver transgenes to target cells.

[origin: CA2328087A1] The invention is directed to novel partially deleted adenoviral vectors (DeAd) in which the majority of adenoviral early genes required for replication are deleted from the vector and placed within the chromosome of a producer cell line under conditional promoter control. The partially deleted adenoviral (DeAd) vectors of the invention can accommodate inserts, such as transgenes, of up to 12-15 kb in size. The invention is further directed to DeAd vector producer cell lines that contain the adenoviral early genes necessary for replication under conditional promoter control that allow for large scale production of vectors. The invention is also directed to methods for the production of DeAd vectors in such cell lines and to the use of such vectors to deliver transgenes to target cells.

IPC 1-7 (main, further and additional classification)

C12N 15/86; C12N 5/10

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01); C12R 1/93 (2006.01)

Citation (search report)

See references of WO 9957296A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

AU 3877099 A 19991123; CA 2328087 A1 19991111; EP 1075532 A1 20010214; JP 2002513582 A 20020514

INPADOC legal status

2004-05-26 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20031101

2001-02-14 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20001130

2001-02-14 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE