Title (en)

SEROTONERGIC AGENTS

Title (de)

SEROTONERGISCHE WIRKSTOFFE

Title (fr)

AGENTS SEROTONINERGIQUES

Publication

EP 1076658 A1 20010221 (EN)

Application

EP 99920078 A 19990428

Priority

• US 9909128 W 19990428
• US 6904198 A 19980429

Abstract (en)

[origin: WO9955697A1] The present invention provides compounds represented by general formula (1), wherein: R1 is selected from H, OH,OR3, F, C1, Br, or I; R2 in each occurrence is H or both together are =O; R3 and R4 are independently selected from H, C1 to C6 alkyl or (CH2)nAr, the alkyl and Ar groups being optionally substituted by from 1 to 3 groups selected from NO2, F, C1, Br, I, -OH, -OR3, C1-C6 alkyl, C1-C6 alkoxy, -CF3, -CN, -S-C1-C6 alkyl, or -NH2; n is selected from 0, 1 or 2; X is CH or CH2; R2 is H or taken together are =O; Ar is aryl or heteroaryl, both optionally substituted; or a pharmaceutically acceptable salt thereof, as well as methods and pharmaceutical compositions utilizing these compounds for the inhibition of serotonin uptake and the treatment of CNS disorders, including depression.

IPC 1-7

C07D 401/14; A61K 31/445; C07D 401/06

IPC 8 full level

A61K 31/4427 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61P 25/16 (2006.01); A61P 25/18 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01); C07D 401/06 (2006.01); C07D 401/14 (2006.01)

CPC (source: EP)

A61P 25/16 (2017.12); A61P 25/18 (2017.12); A61P 25/22 (2017.12); A61P 25/24 (2017.12); A61P 25/28 (2017.12); A61P 43/00 (2017.12); C07D 401/06 (2013.01); C07D 401/14 (2013.01)

Citation (search report)

See references of WO 9955697A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9955697 A1 19991104; AR 015035 A1 20010411; AU 3765899 A 19991116; CA 2330577 A1 19991104; CN 1307576 A 20010808; EP 1076658 A1 20010221; JP 2002513018 A 20020508

DOCDB simple family (application)

US 9909128 W 19990428; AR P990101974 A 19990428; AU 3765899 A 19990428; CA 2330577 A 19990428; CN 99807820 A 19990428; EP 99920078 A 19990428; JP 2000545857 A 19990428