Global patent index - EP 1076658 A1

EP 1076658 A1 2001-02-21 - SEROTONERGIC AGENTS

Title (en)

SEROTONERGIC AGENTS

Title (de)

SEROTONERGISCHE WIRKSTOFFE

Title (fr)

AGENTS SEROTONINERGIQUES

Publication

EP 1076658 A1 (EN)

Application

EP 99920078 A

Priority

  • US 9909128 W
  • US 6904198 A

Abstract (en)

[origin: WO9955697A1] The present invention provides compounds represented by general formula (1), wherein: R1 is selected from H, OH,OR3, F, C1, Br, or I; R2 in each occurrence is H or both together are =O; R3 and R4 are independently selected from H, C1 to C6 alkyl or (CH2)nAr, the alkyl and Ar groups being optionally substituted by from 1 to 3 groups selected from NO2, F, C1, Br, I, -OH, -OR3, C1-C6 alkyl, C1-C6 alkoxy, -CF3, -CN, -S-C1-C6 alkyl, or -NH2; n is selected from 0, 1 or 2; X is CH or CH2; R2 is H or taken together are =O; Ar is aryl or heteroaryl, both optionally substituted; or a pharmaceutically acceptable salt thereof, as well as methods and pharmaceutical compositions utilizing these compounds for the inhibition of serotonin uptake and the treatment of CNS disorders, including depression.

IPC 1-7 (main, further and additional classification)

C07D 401/14; A61K 31/445; C07D 401/06

IPC 8 full level (invention and additional information)

A61K 31/4427 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61P 25/16 (2006.01); A61P 25/18 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01); C07D 401/06 (2006.01); C07D 401/14 (2006.01)

CPC (invention and additional information)

C07D 401/06 (2013.01); C07D 401/14 (2013.01)

Citation (search report)

See references of WO 9955697A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9955697 A1 19991104; AR 015035 A1 20010411; AU 3765899 A 19991116; CA 2330577 A1 19991104; CN 1307576 A 20010808; EP 1076658 A1 20010221; JP 2002513018 A 20020508

INPADOC legal status

2007-12-07 [REG HK WD] APPLICATIONS WITHDRAWN, DEEMED TO BE WITHDRAWN, OR REFUSED AFTER PUBLICATION IN HONG KONG

- Ref Legal Event Code: WD

- Ref Document Number: 1032401

- Country of Ref Document: HK

2002-03-06 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20010823

2001-05-30 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20010412

2001-02-21 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20001002

2001-02-21 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2001-02-21 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Ref Legal Event Code: AX

- Free Format Text: AL PAYMENT 20001002;LT PAYMENT 20001002;LV PAYMENT 20001002;RO PAYMENT 20001002;SI PAYMENT 20001002