EP 1077701 A1 20010228 - ANTI-VIRAL COMPOUNDS
Title (en)
ANTI-VIRAL COMPOUNDS
Title (de)
ANTIVIRALE VERBINDUNGEN
Title (fr)
COMPOSES ANTI-VIRAUX
Publication
Application
Priority
US 9810299 W 19980520
Abstract (en)
[origin: WO9959587A1] The present invention relates to compounds of Formula (I), which inhibit the growth of picornaviruses, Hepatitus viruses, enteroviruses, cardioviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus. In said Formula, A is phenyl, pyridyl, substituted phenyl, substituted pyridyl, or benzyl; R is hydrogen, COR<4>, or COCF3; X is N-OH, O, or CHR<1>; R<1> is hydrogen, halo, CN, C1-C4 alkyl, -CCH, CO(C1-C4 alkyl), CO2(C1-C4 alkyl), or CONR<2>R<3>; R<2> and R<3> are independently hydrogen or C1-C4 alkyl; A' is hydrogen, halo, C1-C6 alkyl, benzyl, naphthyl, thienyl, furyl, pyridyl, pyrollyl, COR<4>, S(O)nR<4>, or a group of formula (II); R<4> is C1-C6 alkyl, phenyl, or substituted phenyl; n is 0, 1, or 2; R<5> is independently at each occurance hydrogen or halo; m is 1, 2, 3, or 4; and R<6> is hydrogen, halo, CF3, OH, CO2H, NH2, NO2, CONHOCH3, C1-C4 alkyl, or CO2(C1-C4 alkyl), C1-C4 alkoxy; or pharmaceutically acceptable salts thereof.
IPC 1-7
IPC 8 full level
A61K 31/437 (2006.01); A61K 31/44 (2006.01); A61K 31/444 (2006.01); A61K 31/50 (2006.01); A61P 1/16 (2006.01); A61P 31/12 (2006.01); C07D 471/04 (2006.01)
IPC 8 main group level
A61K (2006.01)
CPC (source: EP KR)
A61K 31/437 (2013.01 - KR); A61K 31/444 (2013.01 - KR); A61P 1/16 (2018.01 - EP); A61P 31/12 (2018.01 - EP); C07D 471/04 (2013.01 - EP KR)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9959587 A1 19991125; AU 7583098 A 19991206; BR 9815899 A 20010220; CA 2332403 A1 19991125; CN 1292697 A 20010425; CZ 20004278 A3 20010516; CZ 289425 B6 20020116; EA 200001208 A1 20010625; EP 1077701 A1 20010228; EP 1077701 A4 20020320; HU P0102117 A2 20011228; IL 139166 A0 20011125; JP 2002515433 A 20020528; KR 20010025055 A 20010326; NO 20005795 D0 20001116; NO 20005795 L 20010118; SK 17482000 A3 20050304; TR 200003414 T2 20010321
DOCDB simple family (application)
US 9810299 W 19980520; AU 7583098 A 19980520; BR 9815899 A 19980520; CA 2332403 A 19980520; CN 98814051 A 19980520; CZ 20004278 A 19980520; EA 200001208 A 19980520; EP 98923565 A 19980520; HU P0102117 A 19980520; IL 13916698 A 19980520; JP 2000549252 A 19980520; KR 20007012999 A 20001118; NO 20005795 A 20001116; SK 17482000 A 19980520; TR 200003414 T 19980520